Townsend A, Ohlén C, Bastin J, Ljunggren H G, Foster L, Kärre K
Institute of Molecular Medicine, John Radcliffe Hospital, Headington, Oxford, UK.
Nature. 1989 Aug 10;340(6233):443-8. doi: 10.1038/340443a0.
We describe a cell in which association of a major histocompatibility complex class I heavy chain with beta 2-microglobulin is induced by a peptide derived from influenza nucleoprotein. Association of antigenic peptides with the binding site of class I molecules may be required for correct folding of the heavy chain, association with beta 2-microglobulin and transport of the antigen-MHC complex to the cell surface.
我们描述了一种细胞,在其中,来源于流感核蛋白的一种肽可诱导主要组织相容性复合体I类重链与β2-微球蛋白发生结合。I类分子结合位点与抗原肽的结合对于重链的正确折叠、与β2-微球蛋白的结合以及抗原-MHC复合物转运至细胞表面可能是必需的。