Strandberg Kristi L, Rotschafer Jessica H, Schlievert Patrick M
Department of Microbiology, University of Minnesota Medical School, Minneapolis, MN, 55455, USA.
Methods Mol Biol. 2016;1396:81-93. doi: 10.1007/978-1-4939-3344-0_7.
Staphylococcus aureus is a highly significant cause of serious human infections in the USA. Many of these illnesses are mediated by interactions between the host immune system and staphylococcal superantigens (SAgs). Several of these severe staphylococcal infections are initiated in the lungs, making this an important site to study. Here, we describe the rabbit model for investigating the role of staphylococcal SAgs in pulmonary-associated lethal infection and intoxication.
金黄色葡萄球菌是美国严重人类感染的一个非常重要的病因。其中许多疾病是由宿主免疫系统与葡萄球菌超抗原（SAgs）之间的相互作用介导的。这些严重的葡萄球菌感染中有几种始于肺部，使其成为一个重要的研究部位。在这里，我们描述了用于研究葡萄球菌超抗原在肺部相关致死性感染和中毒中作用的兔模型。
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