Issa N, Blondeau B, Dimicoli-Salazar S, Marit G, Morlat P, Camou F
Service de réanimation médicale, hôpital Saint-André, CHU de Bordeaux, 1, rue Jean-Burguet, 33000 Bordeaux, France.
Service de réanimation médicale, hôpital Saint-André, CHU de Bordeaux, 1, rue Jean-Burguet, 33000 Bordeaux, France.
Rev Med Interne. 2016 Aug;37(8):567-9. doi: 10.1016/j.revmed.2015.11.003. Epub 2015 Dec 8.
Hyperammonemia attributed to multiple myeloma has been rarely reported.
We report a 63-year-old man who was admitted to an intensive care unit for confusion and altered mental status progressing to coma that was related to a relapsing multiple myeloma. Chemotherapy allowed the reduction of serum ammonia and the return to a normal state of consciousness.
Hyperammonemic encephalopathy is a rare complication of multiple myeloma and is associated with high in-patient mortality. To our knowledge, this is the first case of hyperammonemic encephalopathy due to a relapsing myeloma diagnosed and treated in intensive care unit.
由多发性骨髓瘤引起的高氨血症鲜有报道。
我们报告一名63岁男性，因意识模糊和精神状态改变进展为昏迷而入住重症监护病房，这与复发性多发性骨髓瘤有关。化疗使血清氨水平降低，意识恢复正常。
高氨血症性脑病是多发性骨髓瘤的一种罕见并发症，与住院患者的高死亡率相关。据我们所知，这是首例在重症监护病房诊断和治疗的由复发性骨髓瘤引起的高氨血症性脑病病例。
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