Abbasi Amanullah, Bhutto Abdul Rabb, Taj Ali, Baloch Akhtar, Masroor Muhammad, Munir S M
Department of Medicine, Medical Unit III, Jinnah Postgraduate Medical Centre (JPMC), Karachi.
Department of Medicine II, Indus Hospital, Karachi.
J Coll Physicians Surg Pak. 2015 Dec;25(12):867-9.
To assess the demographic, clinical, endoscopic and histological spectrum of Solitary Rectal Ulcer Syndrome (SRUS).
Cross-sectional observational study.
Medical Unit-III, Civil Hospital Karachi (CHK) and Ward 7, Jinnah Postgraduate Medical Centre (JPMC), Karachi, from January 2009 to June 2012.
Patients with SRUS, based on characteristic endoscopic and histological findings, were enrolled. Patients were excluded if they had other causes of the rectal lesions (neoplasm, infection, inflammatory bowel disease, and trauma). Endoscopically, lesions were divided on the basis of number (solitary or multiple) and appearance (ulcerative, polypoidal/nodular or erythematous mucosa). Demographic, clinical and endoscopic characteristics of subjects were evaluated.
Forty-four patients met the inclusion criteria; 21 (47.7%) were females and 23 (52.3%) were males with overall mean age of 33.73 ±13.28 years. Symptom-wise 41 (93.2%) had bleeding per rectum, 39 (88.6%) had mucous discharge, 34 (77.3%) had straining, 34 (77.3%) had constipation, 32 (72.7%) had tenesmus, 5 (11.4%) had rectal prolapse and 2 (4.5%) had fecal incontinence. Twelve (27.27%) patients presented with hemoglobin less 10 gm/dl, 27 (61.36%) with 10 - 12 gm/dl and 05 (11.36%) subjects had hemoglobin more than 12 gm/dl. Endoscopically, 26 (59.1%) patients had mucosal ulceration, 11 (25.0%) had mucosal ulceration with polypoid characteristics; while only polypoid features were found in 7 (15.9%) subjects.
Solitary rectal ulcer syndrome affects adults of both genders with diverse clinical presentation and nonspecific endoscopic features.
评估孤立性直肠溃疡综合征（SRUS）的人口统计学、临床、内镜及组织学特征。
横断面观察性研究。
2009年1月至2012年6月，位于卡拉奇市民医院（CHK）的第三内科病房及卡拉奇真纳研究生医学中心（JPMC）的7号病房。
根据特征性内镜及组织学表现纳入SRUS患者。若患者有直肠病变的其他病因（肿瘤、感染、炎症性肠病及创伤）则予以排除。在内镜检查中，病变根据数量（单发或多发）及外观（溃疡性、息肉样/结节状或黏膜红斑）进行分类。评估受试者的人口统计学、临床及内镜特征。
44例患者符合纳入标准；21例（47.7%）为女性，23例（52.3%）为男性，总体平均年龄为33.73 ±13.28岁。按症状分类，41例（93.2%）有直肠出血，39例（88.6%）有黏液便，34例（77.3%）有排便费力，34例（77.3%）有便秘，32例（72.7%）有里急后重，5例（11.4%）有直肠脱垂，2例（4.5%）有大便失禁。12例（27.27%）患者血红蛋白低于10 g/dl，27例（61.36%）为10 - 12 g/dl，5例（11.36%）受试者血红蛋白高于12 g/dl。在内镜检查中，26例（59.1%）患者有黏膜溃疡，11例（25.0%）有伴有息肉样特征的黏膜溃疡；而仅7例（15.9%）受试者有息肉样特征。
孤立性直肠溃疡综合征影响成年男女，临床表现多样，内镜特征不具特异性。
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