心脏疾病建模为其增添了一道 Notch。

Heart disease modelling adds a Notch to its belt.

机构信息

Roddenberry Center for Stem Cell Biology and Medicine, Gladstone Institute of Cardiovascular Disease, 1650 Owens Street, San Francisco, California 94158, USA, and the Departments of Pediatrics and Biochemistry &Biophysics, University of California, San Francisco, 16th Street, San Francisco, California 94143, USA.

出版信息

Nat Cell Biol. 2016 Jan;18(1):3-5. doi: 10.1038/ncb3294.

DOI:10.1038/ncb3294

PMID:26693916

Abstract

The heart is a complex organ, consisting of multiple cell types that coordinately regulate blood flow. Reciprocal Notch pathway signalling in endocardial and myocardial cells is now shown to promote maturation of the ventricular chambers. These insights reveal mechanisms that, when disrupted, can lead to cardiomyopathies.

摘要

心脏是一个复杂的器官，由多种细胞类型组成，这些细胞类型协调调节血流。现在已经表明，心内膜和心肌细胞中的 Notch 通路信号的相互作用可促进心室腔的成熟。这些发现揭示了一些机制，当这些机制被破坏时，可能会导致心肌病。