Kim Seung Hyo, Hong Soon Hyeok
Center for Nanoparticle Research, Institute for Basic Science (IBS) , Seoul 151-742, Republic of Korea.
Department of Chemistry, College of Natural Sciences, Seoul National University , Seoul 151-747, Republic of Korea.
Org Lett. 2016 Jan 15;18(2):212-5. doi: 10.1021/acs.orglett.5b03328. Epub 2015 Dec 22.
An unprecedented protocol for urea synthesis directly from methanol and amine was accomplished. The reaction is highly atom-economical, producing hydrogen as the sole byproduct. Commercially available ruthenium pincer complexes were used as catalysts. In addition, no additive, such as a base, oxidant, or hydrogen acceptor, was required. Furthermore, unsymmetrical urea derivatives were successfully obtained via a one-pot, two-step reaction.
实现了一种前所未有的直接由甲醇和胺合成尿素的方法。该反应具有高度的原子经济性,仅产生氢气作为唯一的副产物。使用市售的钌钳形配合物作为催化剂。此外,无需碱、氧化剂或氢受体等添加剂。而且,通过一锅两步反应成功获得了不对称尿素衍生物。