将人类外分泌胰腺细胞重编程为β细胞。
Reprogramming of human exocrine pancreas cells to beta cells.
作者信息
Staels Willem, Heremans Yves, Heimberg Harry
机构信息
Diabetes Research Center, Vrije Universiteit Brussel, 1090 Brussels, Belgium; Department of Pediatrics, Division of Pediatric Endocrinology, Ghent University Hospital, and Department of Pediatrics and Genetics, Ghent University, Ghent, Belgium.
Diabetes Research Center, Vrije Universiteit Brussel, 1090 Brussels, Belgium.
出版信息
Best Pract Res Clin Endocrinol Metab. 2015 Dec;29(6):849-57. doi: 10.1016/j.beem.2015.10.001. Epub 2015 Oct 9.
One of the key promises of regenerative medicine is providing a cure for diabetes. Cell-based therapies are proving their safety and efficiency, but donor beta cell shortages and immunological issues remain major hurdles. Reprogramming of human pancreatic exocrine cells towards beta cells would offer a major advantage by providing an abundant and autologous source of beta cells. Over the past decade our understanding of transdifferentiation processes greatly increased allowing us to design reprogramming protocols that fairly aim for clinical trials.
再生医学的关键承诺之一是治愈糖尿病。基于细胞的疗法正在证明其安全性和有效性，但供体β细胞短缺和免疫问题仍然是主要障碍。将人类胰腺外分泌细胞重编程为β细胞将提供丰富的自体β细胞来源，从而带来重大优势。在过去十年中，我们对转分化过程的理解有了很大提高，这使我们能够设计出有望用于临床试验的重编程方案。
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