Zhuang J-J, Zheng Y-H, Xu X-W, Zhou L
Neurology Department, Weifang People's Hospital, Weifang, Shandong, China.
Eur Rev Med Pharmacol Sci. 2015 Dec;19(23):4621-6.
OBJECTIVE: Our objective is to determine the value of enhanced substantia nigra echo in the diagnosis of Parkinson's disease by analyzing the intensity and area of substantia nigra echo by transcranial Doppler sonography (TCS). PATIENTS AND METHODS: 36 patients diagnosed as ultra early stage Parkinson's disease between 2013 November and 2014 August were selected as the disease group, and 32 healthy people with the similar representation of age and gender were selected as the control group. TCS was used to detect the echo intensity and the echo intensity of the same location of bilateral hemicerebrum was used to evaluate the bilateral substantia nigra echo. The age and gender were also used for correlation analysis with the results of substantia nigra echo. RESULTS: In the control group, there were 17 patients of substantia nigra echo grade I (53.1%), 13 cases of substantia nigra echo grade II (40.6%), 2 cases of substantia nigra echo grade III (6.3%). While in the disease group, there were 4 cases of substantia nigra echo grade II (11.1%), 13 cases of substantia nigra echo grade III (36.1%), 12 cases of substantia nigra echo grade IV (33.3%) and 7 cases of substantia nigra echo grade V (19.4%). The ratio of enhanced substantia nigra echo in Parkinson's disease patients was significantly higher than the control group. The analysis of the factors related to motor symptoms in Parkinson's disease patients revealed that the area of bilateral substantia nigra echo was negatively correlated with gender, but positively correlated with age, S/M ratio and UPDRS II score. However, there was no correlation with H-Y stage. The sensitivity of substantia nigra echo in diagnosing Parkinson's disease was 32/36=88.89% and the specificity was 30/32 = 93.75%. CONCLUSIONS: Analysis of substantia nigra echo is practically useful for the diagnosis of the ultra early stage Parkinson's disease, which can potentially improve the accuracy of clinical diagnosis to significantly enhance the early clinical prevention and reduce later disability.
目的：通过经颅多普勒超声（TCS）分析黑质回声的强度和面积，确定增强的黑质回声在帕金森病诊断中的价值。 患者与方法：选取2013年11月至2014年8月诊断为超早期帕金森病的36例患者作为疾病组，选取32例年龄、性别相近的健康人作为对照组。采用TCS检测双侧大脑半球同一部位的回声强度，以评估双侧黑质回声。同时对年龄、性别与黑质回声结果进行相关性分析。 结果：对照组中，黑质回声I级17例（53.1%），II级13例（40.6%），III级2例（6.3%）。而疾病组中，黑质回声II级4例（11.1%），III级13例（36.1%），IV级12例（33.3%），V级7例（19.4%）。帕金森病患者黑质回声增强的比例显著高于对照组。对帕金森病患者运动症状相关因素分析显示，双侧黑质回声面积与性别呈负相关，但与年龄、S/M比值及UPDRS II评分呈正相关。与H-Y分期无相关性。黑质回声诊断帕金森病的敏感性为32/36 = 88.89%，特异性为30/32 = 93.75%。 结论：黑质回声分析对超早期帕金森病的诊断具有实际应用价值，可潜在提高临床诊断准确性，显著加强早期临床预防并减少后期残疾。
Eur Rev Med Pharmacol Sci. 2015-12
Parkinsonism Relat Disord. 2015-8
J Neuroimaging. 2007-4
Parkinsonism Relat Disord. 2016-3
Ultrasound Med Biol. 2019-1
Zotero 插件