Heaf James Goya
Department of Medicine, Roskilde Hospital, University of Copenhagen, Copenhagen, Denmark
Perit Dial Int. 2015 Nov;35(6):640-4. doi: 10.3747/pdi.2014.00339.
PURPOSE: The purpose of this paper was to review the literature concerning the treatment of chronic kidney disease-mineral bone disorder (CKD-MBD) in the elderly peritoneal dialysis (PD) patient. RESULTS: Chronic kidney disease-mineral bone disorder is a major problem in the elderly PD patient, with its associated increased fracture risk, vascular calcification, and accelerated mortality fracture risk. Peritoneal dialysis, however, bears a lower risk than hemodialysis (HD). The approach to CKD-MBD prophylaxis and treatment in the elderly PD patient is similar to other CKD patients, with some important differences. Avoidance of hypercalcemia, hyperphosphatemia, and hyperparathyroidism is important, as in other CKD groups, and is generally easier to attain. Calcium-free phosphate binders are recommended for normocalcemic and hypercalcemic patients. Normalization of vitamin D levels to > 75 nmol/L (> 30 pg/L) and low-dose active vitamin D therapy is recommended for all patients. Hyperparathryoidism is to be avoided by using active vitamin D and cinacalcet. Particular attention should be paid to treating protein malnutrition. Fracture prophylaxis (exercise, use of walkers, dwelling modifications) are important. Hypomagnesemia is common in PD and can be treated with magnesium supplements. Vitamin K deficiency is also common and has been identified as a cause of vascular calcification. Accordingly, warfarin treatment for this age group is problematic. CONCLUSION: While treatment principles are similar to other dialysis patient groups, physicians should be aware of the special problems of the elderly group.
目的:本文旨在综述有关老年腹膜透析(PD)患者慢性肾脏病-矿物质和骨异常(CKD-MBD)治疗的文献。 结果:慢性肾脏病-矿物质和骨异常是老年PD患者的一个主要问题,与之相关的骨折风险增加、血管钙化以及死亡率加速上升。然而,腹膜透析的风险低于血液透析(HD)。老年PD患者CKD-MBD的预防和治疗方法与其他CKD患者相似,但存在一些重要差异。与其他CKD群体一样,避免高钙血症、高磷血症和甲状旁腺功能亢进很重要,而且通常更容易实现。对于血钙正常和高钙血症患者,推荐使用不含钙的磷结合剂。建议所有患者将维生素D水平恢复正常至>75 nmol/L(>30 pg/L)并进行低剂量活性维生素D治疗。应通过使用活性维生素D和西那卡塞避免甲状旁腺功能亢进。应特别注意治疗蛋白质营养不良。骨折预防(运动、使用助行器、改造居住环境)很重要。低镁血症在PD患者中很常见,可通过补充镁进行治疗。维生素K缺乏也很常见,并且已被确定为血管钙化的一个原因。因此,该年龄组的华法林治疗存在问题。 结论:虽然治疗原则与其他透析患者群体相似,但医生应意识到老年群体的特殊问题。
Perit Dial Int. 2015-11
Saudi J Kidney Dis Transpl. 2014-11
Rev Cardiovasc Med. 2022-9-16
J Clin Med. 2022-12-28
Am J Kidney Dis. 2014-3-13
J Am Soc Nephrol. 2013-8-15
J Am Soc Nephrol. 2013-6-6
Scand J Urol Nephrol. 2012-12
Contrib Nephrol. 2012