文献检索文档翻译深度研究
Suppr Zotero 插件Zotero 插件
邀请有礼套餐&价格历史记录

新学期,新优惠

限时优惠:9月1日-9月22日

30天高级会员仅需29元

1天体验卡首发特惠仅需5.99元

了解详情
不再提醒
插件&应用
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
高级版
套餐订阅购买积分包
AI 工具
文献检索文档翻译深度研究
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2025

老年腹膜透析患者的慢性肾脏病-矿物质和骨异常

Chronic Kidney Disease-Mineral Bone Disorder in the Elderly Peritoneal Dialysis Patient.

作者信息

Heaf James Goya

机构信息

Department of Medicine, Roskilde Hospital, University of Copenhagen, Copenhagen, Denmark

出版信息

Perit Dial Int. 2015 Nov;35(6):640-4. doi: 10.3747/pdi.2014.00339.


DOI:10.3747/pdi.2014.00339
PMID:26702005
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4689466/
Abstract

PURPOSE: The purpose of this paper was to review the literature concerning the treatment of chronic kidney disease-mineral bone disorder (CKD-MBD) in the elderly peritoneal dialysis (PD) patient. RESULTS: Chronic kidney disease-mineral bone disorder is a major problem in the elderly PD patient, with its associated increased fracture risk, vascular calcification, and accelerated mortality fracture risk. Peritoneal dialysis, however, bears a lower risk than hemodialysis (HD). The approach to CKD-MBD prophylaxis and treatment in the elderly PD patient is similar to other CKD patients, with some important differences. Avoidance of hypercalcemia, hyperphosphatemia, and hyperparathyroidism is important, as in other CKD groups, and is generally easier to attain. Calcium-free phosphate binders are recommended for normocalcemic and hypercalcemic patients. Normalization of vitamin D levels to > 75 nmol/L (> 30 pg/L) and low-dose active vitamin D therapy is recommended for all patients. Hyperparathryoidism is to be avoided by using active vitamin D and cinacalcet. Particular attention should be paid to treating protein malnutrition. Fracture prophylaxis (exercise, use of walkers, dwelling modifications) are important. Hypomagnesemia is common in PD and can be treated with magnesium supplements. Vitamin K deficiency is also common and has been identified as a cause of vascular calcification. Accordingly, warfarin treatment for this age group is problematic. CONCLUSION: While treatment principles are similar to other dialysis patient groups, physicians should be aware of the special problems of the elderly group.

摘要

目的:本文旨在综述有关老年腹膜透析(PD)患者慢性肾脏病-矿物质和骨异常(CKD-MBD)治疗的文献。 结果:慢性肾脏病-矿物质和骨异常是老年PD患者的一个主要问题,与之相关的骨折风险增加、血管钙化以及死亡率加速上升。然而,腹膜透析的风险低于血液透析(HD)。老年PD患者CKD-MBD的预防和治疗方法与其他CKD患者相似,但存在一些重要差异。与其他CKD群体一样,避免高钙血症、高磷血症和甲状旁腺功能亢进很重要,而且通常更容易实现。对于血钙正常和高钙血症患者,推荐使用不含钙的磷结合剂。建议所有患者将维生素D水平恢复正常至>75 nmol/L(>30 pg/L)并进行低剂量活性维生素D治疗。应通过使用活性维生素D和西那卡塞避免甲状旁腺功能亢进。应特别注意治疗蛋白质营养不良。骨折预防(运动、使用助行器、改造居住环境)很重要。低镁血症在PD患者中很常见,可通过补充镁进行治疗。维生素K缺乏也很常见,并且已被确定为血管钙化的一个原因。因此,该年龄组的华法林治疗存在问题。 结论:虽然治疗原则与其他透析患者群体相似,但医生应意识到老年群体的特殊问题。

相似文献

[1]
Chronic Kidney Disease-Mineral Bone Disorder in the Elderly Peritoneal Dialysis Patient.

Perit Dial Int. 2015-11

[2]
Survey of attitudes of physicians toward the current evaluation and treatment of chronic kidney disease-mineral and bone disorder (CKD-MBD).

Saudi J Kidney Dis Transpl. 2010-1

[3]
Management of CKD-MBD in non-dialysis patients under regular nephrology care: a prospective multicenter study.

J Nephrol. 2016-2

[4]
[Changes in mineral metabolism in stage 3, 4, and 5 chronic kidney disease (not on dialysis)].

Nefrologia. 2008

[5]
Trends of elevated parathormone serum titers in hemodialysis patients on intensive therapy for bone disease: a multicenter study.

Saudi J Kidney Dis Transpl. 2014-11

[6]
[Chronic kidney disease (CKD) and bone. Management of chronic kidney disease-mineral and bone disorder in peritoneal dialysis patients].

Clin Calcium. 2009-4

[7]
Prevalence and risk factors for hypercalcemia among non-dialysis patients with chronic kidney disease-mineral and bone disorder.

Int Urol Nephrol. 2018-10

[8]
International variations in serum PTH and calcium levels and their mortality associations in peritoneal dialysis patients: Results from PDOPPS.

Perit Dial Int. 2024-7

[9]
[CKD-MBD (Chronic Kidney Disease-Mineral and Bone Disorder). Role of cinacalcet in the treatment of CKD-MBD].

Clin Calcium. 2010-7

[10]
Phosphate binders, vitamin D and calcimimetics in the management of chronic kidney disease-mineral bone disorders (CKD-MBD) in children.

Pediatr Nephrol. 2013-2-5

引用本文的文献

[1]
Warfarin-Induced Calcification: Potential Prevention and Treatment Strategies.

Rev Cardiovasc Med. 2022-9-16

[2]
Hypomagnesemia as a Risk Factor and Accelerator for Vascular Aging in Diabetes Mellitus and Chronic Kidney Disease.

Metabolites. 2023-2-19

[3]
Review of Isoflavones and Their Potential Clinical Impacts on Cardiovascular and Bone Metabolism Markers in Peritoneal Dialysis Patients.

Prev Nutr Food Sci. 2022-12-31

[4]
Relationship between Residual Urine Output and Type of Dialysis with FGF23 Levels.

J Clin Med. 2022-12-28

[5]
To evaluate the relationship between serum magnesium and parathyroid hormone levels in peritoneal dialysis and hemodialysis patients.

Int Urol Nephrol. 2023-5

[6]
Mineral and bone disorder in hemodialysis patients in the Tibetan Plateau: a multicenter cross-sectional study.

Ren Fail. 2019-11

[7]
Long-term effects on PTH and mineral metabolism of 1.25 versus 1.75 mmol/L dialysate calcium in peritoneal dialysis patients: a meta-analysis.

BMC Nephrol. 2019-6-11

本文引用的文献

[1]
Epidemiology and mortality of hip fracture among patients on dialysis: Taiwan National Cohort Study.

Bone. 2014-7

[2]
Fragility fractures and osteoporosis in CKD: pathophysiology and diagnostic methods.

Am J Kidney Dis. 2014-3-13

[3]
Randomized, controlled trial of glucose-sparing peritoneal dialysis in diabetic patients.

J Am Soc Nephrol. 2013-8-15

[4]
High rates of death and hospitalization follow bone fracture among hemodialysis patients.

Kidney Int. 2014-1

[5]
Temporal trends in fracture rates and postdischarge outcomes among hemodialysis patients.

J Am Soc Nephrol. 2013-6-6

[6]
Temporal trends in the incidence, treatment, and outcomes of hip fracture in older patients initiating dialysis in the United States.

Clin J Am Soc Nephrol. 2013-5-9

[7]
Low-calcium dialysate as a risk factor for decline in bone mineral density in peritoneal dialysis patients.

Scand J Urol Nephrol. 2012-12

[8]
Bone microarchitecture is more severely affected in patients on hemodialysis than in those receiving peritoneal dialysis.

Kidney Int. 2012-6-20

[9]
Vitamin K, vertebral fractures, vascular calcifications, and mortality: VItamin K Italian (VIKI) dialysis study.

J Bone Miner Res. 2012-11

[10]
Role of vitamin D receptor activators in peritoneal dialysis.

Contrib Nephrol. 2012

文献AI研究员

20分钟写一篇综述,助力文献阅读效率提升50倍

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

推荐工具

医学文档翻译智能文献检索