Guo Hongrui, Chen Lian, Cui Hengmin, Peng Xi, Fang Jing, Zuo Zhicai, Deng Junliang, Wang Xun, Wu Bangyuan
Key Laboratory of Animal Diseases and Environmental Hazards of Sichuan Province, Sichuan Agricultural University, Ya'an 625014, China.
College of Veterinary Medicine, Sichuan Agricultural University Ya'an, Ya'an 625014, China.
Int J Mol Sci. 2015 Dec 23;17(1):10. doi: 10.3390/ijms17010010.
High concentrations of nickel (Ni) are harmful to humans and animals. Ni targets a number of organs and produces multiple toxic effects. Apoptosis is important in Ni-induced toxicity of the kidneys, liver, nerves, and immune system. Apoptotic pathways mediated by reactive oxygen species (ROS), mitochondria, endoplasmic reticulum (ER), Fas, and c-Myc participate in Ni-induced cell apoptosis. However, the exact mechanism of apoptosis caused by Ni is still unclear. Understanding the mechanism of Ni-induced apoptosis may help in designing measures to prevent Ni toxicity.
高浓度镍（Ni）对人类和动物有害。镍会靶向多个器官并产生多种毒性作用。细胞凋亡在镍诱导的肾脏、肝脏、神经和免疫系统毒性中起重要作用。由活性氧（ROS）、线粒体、内质网（ER）、Fas和c-Myc介导的凋亡途径参与镍诱导的细胞凋亡。然而，镍引起细胞凋亡的确切机制仍不清楚。了解镍诱导细胞凋亡的机制可能有助于设计预防镍毒性的措施。
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