Wang Lei, Yu Wei-bo, Tao Lian-yuan, Xu Qing
Department of General Surgery, Beijing Charity Hospital, China Rehabilitation Research Center, Rehabilitation College of Capital Medical University, Beijing, China.
Department of General Surgery, Peking University Third Hospital, Beijing, China.
J Neuroimmunol. 2016 Jan 15;290:96-102. doi: 10.1016/j.jneuroim.2015.11.023. Epub 2015 Nov 27.
Spinal cord injury (SCI) is characterized by the loss of motor and sensory functions in areas below the level of the lesion and numerous accompanying deficits. Previous studies have suggested that myeloid-derived suppressor cell (MDSC)-induced immune depression may play a pivotal role in the course of SCI. However, the concrete mechanism of these changes regarding immune suppression remains unknown. Here, we created an SCI mouse model to gain further evidence regarding the relationship between MDSCs following SCI and T lymphocyte suppression. We showed that in the SCI mouse model, the expanding MDSCs have the capacity to suppress T cell proliferation, and this suppression could be reversed by blocking the arginase.
脊髓损伤（SCI）的特征是损伤水平以下区域的运动和感觉功能丧失以及许多伴随的缺陷。先前的研究表明，髓源性抑制细胞（MDSC）诱导的免疫抑制可能在SCI病程中起关键作用。然而，这些免疫抑制相关变化的具体机制仍不清楚。在此，我们创建了一个SCI小鼠模型，以获得关于SCI后MDSC与T淋巴细胞抑制之间关系的进一步证据。我们发现，在SCI小鼠模型中，不断扩增的MDSC具有抑制T细胞增殖的能力，并且这种抑制作用可通过阻断精氨酸酶来逆转。
