Lee Y H, Bae S-C
Korea University College of Medicine Division of Rheumatology, Department of Internal Medicine Seoul Republic of Korea
Hanyang University Hospital for Rheumatic Diseases Department of Rheumatology Seoul Republic of Korea.
Cell Mol Biol (Noisy-le-grand). 2015 Dec 26;61(8):97-104.
This study aimed to explore whether the functional CD24 A57V and TG/del polymorphisms are associated with susceptibility to autoimmune diseases. A meta-analysis was conducted on the associations between the CD24 A57V and TG/del polymorphisms and autoimmune diseases using (1) allele contrast, and (2) the recessive, (3) dominant, and (4) co-dominant models. Twenty-six comparative studies with 7,507 patients and 8,803 controls were included in the meta-analysis. The meta-analysis revealed a significant association between autoimmune disease and the CD24 Val allele (OR = 1.285, 95% CI = 1.177-1.403, p = 1.0 × 10-9). Meta-analysis by autoimmune disease type showed a significant association between the CD24 Val allele and multiple sclerosis (MS) (OR = 1.420, 95% CI = 1.239-1.628, p = 4.7 × 10-8) and systemic lupus erythematous (SLE) (OR = 1.282, 95% CI = 1.081-1.521, p = 0.004), but not Crohn's disease (CD) (OR = 1.003, 95% CI = 0.826-1.218, p = 0.974). Meta-analysis of the CD24 Val/Val genotype showed an association with ulcerative colitis (OR = 1.778, 95% CI = 1.148-2.753, p = 0.010). In addition, meta-analysis by autoimmune disease type revealed a significant association between the CD24 TG-deletion allele and MS (OR = 0.596, 95% CI = 0.415-0.856, p = 0.005) and CD (OR = 1.594, 95% CI = 1.175-2.161, p = 0.003). This meta-analysis indicates that the functional CD24 A57V and TG/del polymorphisms are associated with susceptibility to multiple autoimmune diseases including SLE, MS, UC and CD.
本研究旨在探讨功能性CD24 A57V和TG/del多态性是否与自身免疫性疾病易感性相关。采用（1）等位基因对比、（2）隐性模型、（3）显性模型和（4）共显性模型，对CD24 A57V和TG/del多态性与自身免疫性疾病之间的关联进行了荟萃分析。荟萃分析纳入了26项比较研究，共7507例患者和8803例对照。荟萃分析显示自身免疫性疾病与CD24缬氨酸等位基因之间存在显著关联（OR = 1.285，95%CI = 1.177 - 1.403，p = 1.0×10−9）。按自身免疫性疾病类型进行的荟萃分析显示，CD24缬氨酸等位基因与多发性硬化症（MS）（OR = 1.420，95%CI = 1.239 - 1.628，p = 4.7×10−8）和系统性红斑狼疮（SLE）（OR = 1.282，95%CI = 1.081 - 1.521，p = 0.004）之间存在显著关联，但与克罗恩病（CD）无关（OR = 1.003，95%CI = 0.826 - 1.218，p = 0.974）。对CD24 Val/Val基因型的荟萃分析显示与溃疡性结肠炎相关（OR = 1.778，95%CI = 1.148 - 2.753，p = 0.010）。此外，按自身免疫性疾病类型进行的荟萃分析显示，CD24 TG缺失等位基因与MS（OR = 0.596，95%CI = 0.415 - 0.856，p = 0.005）和CD（OR = 1.594，95%CI = 1.175 - 2.161，p = 0.003）之间存在显著关联。这项荟萃分析表明，功能性CD24 A57V和TG/del多态性与包括SLE、MS、UC和CD在内的多种自身免疫性疾病的易感性相关。
