Department of Systems Physiology, University of the Ryukyus Graduate School of Medicine, 207 Uehara, Nishihara, Okinawa, 903-0215, Japan.
Tokyo Medical and Dental University, Tokyo, Japan.
J Physiol Sci. 2016 Jul;66(4):293-301. doi: 10.1007/s12576-015-0431-2. Epub 2015 Dec 30.
Throughout our investigations on the ontogenesis of the electrophysiological events in early embryonic chick hearts, using optical techniques to record membrane potential probed with voltage-sensitive dyes, we have introduced a novel concept of "functiogenesis" corresponding to "morphogenesis". This article gives an account of the framework of "functiogenesis", focusing on the cardiac pacemaker function and the functional organization of the pacemaking area.
在我们使用光学技术记录电压敏感染料探测的细胞膜电位,以研究早期鸡胚心脏中电生理事件的个体发生的整个过程中,引入了一个对应于“形态发生”的新概念“功能发生”。本文介绍了“功能发生”的框架,重点介绍了心脏起搏功能和起搏区的功能组织。