铂类化疗成功治疗两例连续性肺多形性癌
Successful treatment of two consecutive cases of pulmonary pleomorphic carcinoma with platinum chemotherapy.
作者信息
Kato Daisuke, Chihara Yuichi, Shirase Tomoyuki, Takahashi Tamaki, Takahashi Ken-Ichi, Sakai Naoki
机构信息
Respiratory Disease Center, Otsu Red Cross Hospital, Otsu, Shiga 520-8511, Japan.
Department of Pathology, Otsu Red Cross Hospital, Otsu, Shiga 520-8511, Japan.
出版信息
Oncol Lett. 2015 Nov;10(5):3040-3042. doi: 10.3892/ol.2015.3678. Epub 2015 Sep 3.
Abstract
Pulmonary pleomorphic carcinoma (PPC) is a rare pulmonary malignant tumor that has a more aggressive clinical course and a poorer prognosis compared with non-small cell lung cancer (NSCLC) due to its resistance to chemotherapy and radiotherapy. In patients with advanced or relapsed PPC, it has been reported that the response rate to chemotherapy regimens known to be effective in patients with NSCLC is only 0-17%. The present study reports the cases of two consecutive patients with advanced PPC who exhibited marked responses to chemotherapy with carboplatin plus paclitaxel chemotherapy and long-term survival without tumor progression. This suggests that carboplatin plus paclitaxel chemotherapy is a good option for the treatment of advanced PPC.
摘要
肺多形性癌（PPC）是一种罕见的肺恶性肿瘤，由于其对化疗和放疗具有抗性，与非小细胞肺癌（NSCLC）相比，具有更具侵袭性的临床病程和更差的预后。据报道，在晚期或复发的PPC患者中，对已知对NSCLC患者有效的化疗方案的缓解率仅为0-17%。本研究报告了两名连续的晚期PPC患者的病例，他们对卡铂加紫杉醇化疗表现出显著反应，并长期生存且无肿瘤进展。这表明卡铂加紫杉醇化疗是治疗晚期PPC的一个良好选择。
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