Zhang Tao, Du Jian, Yin Xiaoyan, Xue Fuzhong, Liu Yanxun, Li Runzi, Luo Cheng, Li Liang, Li Xiujun
Department of Biostatistics, School of Public Health, Shandong University, Jinan 250012, China.
Clinical Center Office, Beijing Tuberculosis and Thoracic Tumor Research Institute, Beijing 101149, China.
Int J Environ Res Public Health. 2015 Dec 29;13(1):86. doi: 10.3390/ijerph13010086.
This study aimed to estimate the adverse events (AE) rate during anti-tuberculosis treatment and to explore AE-related risk factors. New and previously treated smear-positive tuberculosis (TB) cases were enrolled from eight regions in China between April 2009 and October 2010. The AE rate was estimated, and AE risk factors during anti-TB treatment were assessed using Cox proportional models. Among 2091 Chinese subjects with anti-TB treatment, 462 (22.1%, 95% confidence interval (CI), 20.3-23.9) patients developed AE, with liver injury and gastrointestinal reactions constituting the most common AE. Specifically, 9.8% (95% CI, 8.5-11.1) and 6.3% (95% CI, 5.3-7.4) developed liver injuries and gastrointestinal reactions, respectively. We found that AE rate differed by regions, TB knowledge score, symptoms score and smoking status. Liver injuries were associated with age, sex and smoking status; gastrointestinal reactions were associated with education level and symptom score. Improving patients' knowledge on TB could reduce AE rate.
本研究旨在估算抗结核治疗期间的不良事件（AE）发生率，并探索与AE相关的危险因素。2009年4月至2010年10月期间，从中国八个地区招募了新发病例和既往接受过治疗的涂片阳性肺结核（TB）病例。估算了AE发生率，并使用Cox比例模型评估了抗结核治疗期间的AE危险因素。在2091例接受抗结核治疗的中国受试者中，462例（22.1%，95%置信区间（CI），20.3 - 23.9）患者发生了AE，其中肝损伤和胃肠道反应是最常见的AE。具体而言，分别有9.8%（95%CI，8.5 - 11.1）和6.3%（95%CI，5.3 - 7.4）的患者发生了肝损伤和胃肠道反应。我们发现AE发生率因地区、结核病知识得分、症状得分和吸烟状况而异。肝损伤与年龄、性别和吸烟状况有关；胃肠道反应与教育水平和症状得分有关。提高患者对结核病的认识可降低AE发生率。
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