癌症：寄希望于耐药性。 - Suppr

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超能文献

Cancer: Bet on drug resistance.

作者信息

Settleman Jeff

机构信息

Calico Life Sciences, South San Francisco, California 94080, USA.

出版信息

Nature. 2016 Jan 21;529(7586):289-90. doi: 10.1038/nature16863. Epub 2016 Jan 6.

DOI:10.1038/nature16863

PMID:26735017

Abstract

摘要

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本文引用的文献

Response and resistance to BET bromodomain inhibitors in triple-negative breast cancer.三阴性乳腺癌对BET溴结构域抑制剂的反应与耐药性

Nature. 2016 Jan 21;529(7586):413-417. doi: 10.1038/nature16508. Epub 2016 Jan 6.

Transcriptional plasticity promotes primary and acquired resistance to BET inhibition.转录可塑性促进对BET抑制的原发性和获得性耐药。

Nature. 2015 Sep 24;525(7570):543-547. doi: 10.1038/nature14898. Epub 2015 Sep 14.

BET inhibitor resistance emerges from leukaemia stem cells.白血病干细胞产生对BET抑制剂的耐药性。

Nature. 2015 Sep 24;525(7570):538-42. doi: 10.1038/nature14888. Epub 2015 Sep 14.

A comprehensive transcriptional portrait of human cancer cell lines.人类癌细胞系的全面转录组图谱。

Nat Biotechnol. 2015 Mar;33(3):306-12. doi: 10.1038/nbt.3080. Epub 2014 Dec 8.

Bromodomain and extraterminal domain inhibitors (BETi) for cancer therapy: chemical modulation of chromatin structure.用于癌症治疗的溴结构域和额外末端结构域抑制剂（BETi）：染色质结构的化学调控

Cold Spring Harb Perspect Biol. 2014 Dec 1;6(12):a018663. doi: 10.1101/cshperspect.a018663.

Mechanisms of acquired resistance to targeted cancer therapies.获得性耐药的机制对靶向癌症治疗。

Future Oncol. 2012 Aug;8(8):999-1014. doi: 10.2217/fon.12.86.

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EMT, cancer stem cells and drug resistance: an emerging axis of evil in the war on cancer.急诊医师、癌症干细胞和耐药性：抗癌之战中的新兴邪恶轴心。

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