Synthesis and biological evaluation of novel dioxa-bicycle C-aryl glucosides as SGLT2 inhibitors.
作者信息
Yan Qi, Ding Ning, Li Yingxia
机构信息
School of Pharmacy, Fudan University, Shanghai 201203, China.
School of Pharmacy, Fudan University, Shanghai 201203, China.
出版信息
Carbohydr Res. 2016 Feb 8;421:1-8. doi: 10.1016/j.carres.2015.10.011. Epub 2015 Dec 7.
PMID:26735747
Abstract
A series of novel C-aryl glucosides containing dioxa-bicycle were synthesized and evaluated for inhibition activity against hSGLT2. Among the compounds tested, compound 6a showed moderate SGLT2 inhibition activities at 700 nM. The results could benefit the discovery of new SGLT2 inhibitors.
摘要
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