Budidha K, Abay T Y, Kyriacou P A
Annu Int Conf IEEE Eng Med Biol Soc. 2015;2015:6417-20. doi: 10.1109/EMBC.2015.7319861.
Continuous assessment of blood flow, blood volume, and blood and tissue oxygenation are of vital importance in critically ill patients. Photoplethysmography (PPG), Pulse Oximetry (PO), Laser Doppler Flowmetry (LDF) and Near Infrared Spectroscopy (NIRS) are amongst the most widely used techniques to monitor such perfusion parameters. In this study, we investigated the feasibility of using dual-wavelength PPG signals on providing comparable information as LDF and NIRS, besides arterial oxygen saturation (SpO2) as measured by pulse oximetry. All three techniques were investigated on six healthy volunteers during whole-body cold exposure. PPG and LDF sensors were attached on the finger and hand respectively, while NIRS was positioned above the left forearm. Measurements at room temperature (24°C) were followed and preceded by a cold exposure (10°C). The results showed that changes in pulsatile PPG amplitudes and hemoglobin concentration estimated from finger PPG signals indicate strong similarities with gold-standard LDF and NIRS measurements.
对危重症患者持续评估血流、血容量以及血液和组织氧合至关重要。光电容积脉搏波描记法（PPG）、脉搏血氧饱和度测定法（PO）、激光多普勒血流仪（LDF）和近红外光谱法（NIRS）是监测此类灌注参数最广泛使用的技术。在本研究中，我们除了研究脉搏血氧饱和度测定法所测量的动脉血氧饱和度（SpO2）外，还研究了使用双波长PPG信号提供与LDF和NIRS可比信息的可行性。在全身冷暴露期间，对六名健康志愿者的所有三种技术进行了研究。PPG和LDF传感器分别连接在手指和手部，而NIRS放置在左前臂上方。在室温（24°C）下进行测量，在冷暴露（10°C）之前和之后也进行了测量。结果表明，从手指PPG信号估计的搏动性PPG幅度和血红蛋白浓度的变化与金标准LDF和NIRS测量结果有很强的相似性。
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