Zhou Yongjing, Wei Feifei, Fan Yu
Institute of Molecular Biology & Translational Medicine, the Affiliated People's Hospital, Jiangsu University, Zhenjiang, Jiangsu, PR China (212002).
Institute of Molecular Biology & Translational Medicine, the Affiliated People's Hospital, Jiangsu University, Zhenjiang, Jiangsu, PR China (212002).
Clin Biochem. 2016 May;49(7-8):636-42. doi: 10.1016/j.clinbiochem.2015.12.010. Epub 2015 Dec 29.
Emerging evidence connects serum uric acid (SUA) levels to nonalcoholic fatty liver disease (NAFLD). The objective of this study was to systematically evaluate the association between SUA levels and risk of NAFLD by conducting a meta-analysis of available observational studies.
We searched for relevant studies in PubMed, Embase, China National Knowledge Infrastructure, and Wanfang databases until October 2014. All observational studies that evaluated SUA levels and NAFLD risks were included. Pooled adjusted odds ratio (OR) and corresponding 95% confidence intervals (CI) were calculated comparing the highest to lowest SUA category.
Four cross-sectional studies, two prospective studies, and three retrospective studies involving 55,573 participants were identified. In overall risk estimates, the pooled OR of NAFLD occurrence was 1.92 (95% CI: 1.59-2.31) comparing the highest to lowest SUA levels in a random effect model. Subgroup analysis showed that high SUA levels increased the risk of NAFLD in cross-sectional studies (OR: 2.18; 95% CI: 1.58-3.03), retrospective studies (OR 1.82; 95% CI: 1.43-2.33), and prospective studies (OR 1.43; 95% CI: 1.20-1.71). The risk of NAFLD seemed more pronounced among women (OR 1.85; 95% CI: 1.43-2.38) than among men (OR 1.56; 95% CI: 1.30-1.86).
This meta-analysis suggests that increased SUA level is associated with an exacerbated risk of NAFLD. This increased risk is probably independent of conventional NAFLD risk factors.
新出现的证据将血清尿酸（SUA）水平与非酒精性脂肪性肝病（NAFLD）联系起来。本研究的目的是通过对现有观察性研究进行荟萃分析，系统评估SUA水平与NAFLD风险之间的关联。
我们在PubMed、Embase、中国知网和万方数据库中检索相关研究，截至2014年10月。纳入所有评估SUA水平和NAFLD风险的观察性研究。计算比较最高与最低SUA类别时的合并调整比值比（OR）及相应的95%置信区间（CI）。
共识别出四项横断面研究、两项前瞻性研究和三项回顾性研究，涉及55573名参与者。在总体风险估计中，随机效应模型下比较最高与最低SUA水平时，NAFLD发生的合并OR为1.92（95%CI：1.59 - 2.31）。亚组分析显示，在横断面研究（OR：2.18；95%CI：1.58 - 3.03）、回顾性研究（OR 1.82；95%CI：1.43 - 2.33）和前瞻性研究（OR 1.43；95%CI：1.20 - 1.71）中，高SUA水平均增加了NAFLD风险。NAFLD风险在女性中（OR 1.85；95%CI：1.43 - 2.38）似乎比男性中（OR 1.56；95%CI：1.30 - 1.86）更为明显。
这项荟萃分析表明，SUA水平升高与NAFLD风险加剧相关。这种增加的风险可能独立于传统的NAFLD风险因素。
