Yu Qiong, Guan Qun, Li Ping, Liu Tie-Bing, Huang Xiao-Lin, Zhao Ying, Liu Hong-Xing, Wang Yuan-Qing
School of Electronic Science and Engineering, Nanjing University, Xianlin Campus, Nanjing, 210023, China.
Nanjing General Hospital of Nanjing Military Command, Nanjing, 210002, China.
Biomed Eng Online. 2016 Jan 8;15(1):4. doi: 10.1186/s12938-015-0118-1.
Almost all promising non-invasive foetal ECG extraction methods involve accurately determining maternal ECG R-wave peaks. However, it is not easy to robustly detect accurate R-wave peaks of the maternal ECG component in an acquired abdominal ECG since it often has a low signal-to-noise ratio (SNR), sometimes containing a large foetal ECG component or other noises and interferences. This paper discusses, under the condition of acquiring multi-channel abdominal ECG signals, how to improve the robustness of maternal ECG R-wave peak detection.
On the basis of summarising the current single channel ECG R-wave peak detection methods, the paper proposed a specific fusion algorithm of detected multi-channel maternal ECG R-wave peak locations. The proposed entire algorithm was then tested using two databases; one database, created by us, was composed of 343 groups of 8-channel data collected from 78 pregnant women, and the other one, called the challenge database, was from the Physionet/Computing in Cardiology Challenge 2013, including 175 groups of 4-channel data. When using these databases, each group of data was classified into two parts, called the training part and the validation test part respectively; the training part was the first 8.192 s of each group of data and the validation test part was the next 8.192 s.
To show the results, three evaluation parameters-sensitivity (Se), positive predictive value (PPV) and F1-are used. The validation test results for the database we collected are Se = 99.93 %, PPV = 99.98 %, and F1 = 99.95 %, while the results for the challenge database are Se = 99.91 %, PPV = 99.86 %, and F1 = 99.88 %.
The results of the test show that the robustness of our proposed whole fusion algorithm was superior to that of other outstanding algorithms for maternal R-wave detection, and is much better than that of single channel maternal R-wave detection algorithms.
几乎所有有前景的无创胎儿心电图提取方法都涉及准确确定母体心电图R波峰值。然而,在采集到的腹部心电图中稳健地检测出母体心电图成分的准确R波峰值并非易事,因为其信噪比(SNR)往往较低,有时还包含大量胎儿心电图成分或其他噪声及干扰。本文探讨在采集多通道腹部心电图信号的条件下,如何提高母体心电图R波峰值检测的稳健性。
在总结当前单通道心电图R波峰值检测方法的基础上,本文提出了一种检测多通道母体心电图R波峰值位置的特定融合算法。然后使用两个数据库对所提出的整个算法进行测试;一个由我们创建的数据库,由从78名孕妇收集的343组8通道数据组成,另一个称为挑战数据库,来自2013年生理网/心脏病学计算挑战赛,包括175组4通道数据。使用这些数据库时,每组数据被分为两部分,分别称为训练部分和验证测试部分;训练部分是每组数据的前8.192秒,验证测试部分是接下来的8.192秒。
为展示结果,使用了三个评估参数——灵敏度(Se)、阳性预测值(PPV)和F1。我们收集的数据库的验证测试结果为Se = 99.93%,PPV = 99.98%,F1 = 99.95%,而挑战数据库的结果为Se = 99.91%,PPV = 99.86%,F1 = 99.88%。
测试结果表明,我们提出的整个融合算法的稳健性优于其他用于母体R波检测的优秀算法,且远优于单通道母体R波检测算法。