2001年至2011年伊朗亚兹德妊娠滋养细胞疾病患者的危险因素、分期及结局研究
Investigation of Risk Factors, Stage and Outcome in Patients with Gestational Trophoblastic Disease since 2001 to 2011 in Iran-Yazd.
作者信息
Karimi-Zarchi Mojgan, Mortazavizadeh Mohammad Reza, Soltani-Gerdefaramrzi Malihe, Rouhi Mitra, Yazdian-Anari Pouria, Ahmadiyeh Mohammad Hosain
机构信息
Associated professor, Department of Gynecology Oncology, Clinical Research Development, Shahid Sadoughi University of Medical Science, Yazd, Iran;
Assistant professor, Hematology and oncology, hematology and oncology department, Islamic Azad University, Yazd branch, Iran;
出版信息
Int J Biomed Sci. 2015 Dec;11(4):166-72.
BACKGROUND AND AIM
Gestational trophoblastic disease (GTN) is one of the high-risk forms of pregnancy that requires a lot of attention in terms of research studies, considering its incidence and the importance of the disease in advanced form. The aim of this study was to investigate the risk factors and clinical procedure of patients with gestational trophoblastic disease from 2001 to 2002.
METHOD OF STUDY
This is a retrospective descriptive study, which was carried out on 150 patients with trophoblastic disease. These patients' files were obtained from Shohadaye Kargar and Shahid Sadoughi hospitals and women's oncology offices of Yazd city. The patients were contacted one by one and their disease situation was determined. The data obtained were recorded in a questionnaire and analyzed by SPSS software.
RESULT
The results indicated that the average age of the patients was 27.65 ± 8.22 with variations in age ranging from 15 to 35 year. In addition, majorities were in the age group of 20 to 40 years. 43.2 percent of the women were affected during their first gestation. 4% had molar gestation record, and 9.4% had positive family record. Mean time of survival was 93.38 ± 0.62 months (MIN ± SE), and only one died owing to chemotherapy complication. Vaginal bleeding (90%) was the most common symptom. 54.6 percent of the disease had complete mole, 30% had incomplete mole, 8.6% had invasive mole, 4.6% had choriocarcinoma and 2% had placenta site trophoblastic tumor (PSTT). Among the patients studied, 28.7% were benign in GTN group while 71.3 % were malignant in the GTN group. The malignant patients were divided into three groups per risk, and 41.2% were in the high-risk group. There was theca-lutein cyst in 54% of the patients, which had a significant relationship with the disease risk of persistent GTN.
CONCLUSION
Choriocarcinoma and invasive mole is the most malignant pathology. There was significant relationship between disease interval and the beginning of chemotherapy, and theca lutein cyst and persistent GTN.
背景与目的
妊娠滋养细胞疾病（GTN）是一种高危妊娠形式，鉴于其发病率及晚期疾病的重要性，在研究方面需要高度关注。本研究的目的是调查2001年至2002年妊娠滋养细胞疾病患者的危险因素及临床过程。
研究方法
这是一项回顾性描述性研究，对150例滋养细胞疾病患者进行。这些患者的病历来自设拉子的卡尔加尔医院、萨杜基医院以及亚兹德市的女性肿瘤科室。逐一联系患者并确定其病情。将获得的数据记录在问卷中，并通过SPSS软件进行分析。
结果
结果表明，患者的平均年龄为27.65±8.22岁，年龄范围在15至35岁之间。此外，大多数患者年龄在20至40岁之间。43.2%的女性在首次妊娠期间患病。4%有葡萄胎妊娠记录，9.4%有阳性家族史。平均生存时间为93.38±0.62个月（最小值±标准误），仅有1例因化疗并发症死亡。阴道出血（90%）是最常见的症状。54.6%的疾病为完全性葡萄胎，30%为不完全性葡萄胎，8.6%为侵蚀性葡萄胎，4.6%为绒毛膜癌，2%为胎盘部位滋养细胞肿瘤（PSTT）。在所研究的患者中，GTN组28.7%为良性，而GTN组71.3%为恶性。恶性患者按风险分为三组，4开.2%属于高危组。54%的患者有黄素化囊肿，其与持续性GTN的疾病风险有显著关系。
结论
绒毛膜癌和侵蚀性葡萄胎是最恶性的病理类型。疾病间隔与化疗开始之间、黄素化囊肿与持续性GTN之间存在显著关系。
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