来自糖尿病控制与并发症试验及糖尿病干预与并发症流行病学研究（DCCT/EDIC）的1型糖尿病患者颈动脉内膜中层厚度和脂蛋白亚类数据。

Data on carotid intima-media thickness and lipoprotein subclasses in type 1 diabetes from the Diabetes Control and Complications Trial and the Epidemiology of Diabetes Interventions and Complications (DCCT/EDIC).

作者信息

Basu Arpita, Jenkins Alicia J, Zhang Ying, Stoner Julie A, Klein Richard L, Lopes-Virella Maria F, Timothy Garvey W, Lyons Timothy J

机构信息

Department of Nutritional Sciences, Oklahoma State University, Stillwater, OK, USA.

Section of Endocrinology & Diabetes, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA; University of Sydney, NHMRC Clinical Trials Centre, Camperdown, Sydney, NSW, Australia.

出版信息

Data Brief. 2015 Nov 22;6:33-8. doi: 10.1016/j.dib.2015.11.036. eCollection 2016 Mar.

DOI:10.1016/j.dib.2015.11.036

PMID:26759826

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4683326/

Abstract

Type 1 diabetes (T1DM) is associated with increased risk of macrovascular complications. We examined longitudinal associations of serum conventional lipids and nuclear magnetic resonance (NMR)-determined lipoprotein subclasses with carotid intima-media thickness (IMT) in adults with T1DM (n=455) enrolled in the Diabetes Control and Complications Trial (DCCT). Data on serum lipids and lipoproteins were collected at DCCT baseline (1983-89) and were correlated with common and internal carotid IMT determined by ultrasonography during the observational follow-up of the DCCT, the Epidemiology of Diabetes Interventions and Complications (EDIC) study, at EDIC 'Year 1' (199-1996) and EDIC 'Year 6' (1998-2000). This article contains data on the associations of DCCT baseline lipoprotein profiles (NMR-based VLDL & chylomicrons, IDL/LDL and HDL subclasses and 'conventional' total, LDL-, HDL-, non-HDL-cholesterol and triglycerides) with carotid IMT at EDIC Years 1 and 6, stratified by gender. The data are supplemental to our original research article describing detailed associations of DCCT baseline lipids and lipoprotein profiles with EDIC Year 12 carotid IMT (Basu et al. in press) [1].

摘要

1型糖尿病（T1DM）与大血管并发症风险增加相关。我们在参与糖尿病控制与并发症试验（DCCT）的成年T1DM患者（n = 455）中，研究了血清常规脂质和核磁共振（NMR）测定的脂蛋白亚类与颈动脉内膜中层厚度（IMT）的纵向关联。血清脂质和脂蛋白数据在DCCT基线期（1983 - 1989年）收集，并与在DCCT观察性随访、糖尿病干预与并发症流行病学（EDIC）研究中于EDIC“第1年”（199 - 1996年）和EDIC“第6年”（1998 - 2000年）通过超声检查测定的颈总动脉和颈内动脉IMT进行关联分析。本文包含了DCCT基线脂蛋白谱（基于NMR的极低密度脂蛋白和乳糜微粒、中间密度脂蛋白/低密度脂蛋白以及高密度脂蛋白亚类，以及“常规”总胆固醇、低密度脂蛋白胆固醇、高密度脂蛋白胆固醇、非高密度脂蛋白胆固醇和甘油三酯）与EDIC第1年和第6年颈动脉IMT的关联数据，按性别分层。这些数据是对我们原始研究文章的补充，该文章描述了DCCT基线脂质和脂蛋白谱与EDIC第12年颈动脉IMT的详细关联（Basu等人，即将发表）[1]。