血管内大B细胞淋巴瘤的自发消退及淋巴瘤细胞凋亡：一例报告

Spontaneous Regression of Intravascular Large B-Cell Lymphoma and Apoptosis of Lymphoma Cells: A Case Report.

作者信息

Takahashi Tsutomu, Ikejiri Fumiyoshi, Takami Saki, Okada Takahiro, Kumanomidou Satoshi, Adachi Koji, Yumi Jo, Onishi Chie, Kawakami Koshi, Moriyama Ichiro, Inoue Masaya, Miyake Takaaki, Tanaka Junko, Maruyama Riruke, Suzumiya Junji

机构信息

Department of Oncology/Hematology, Shimane　University Hospital.

出版信息

J Clin Exp Hematop. 2015;55(3):151-6. doi: 10.3960/jslrt.55.151.

DOI:10.3960/jslrt.55.151

PMID:26763363

Abstract

A 61-year-old Japanese woman presented with hemophagocytic syndrome (HPS) and suffered from intravascular large B-cell lymphoma (IVLBCL). After a few days of supportive care, her condition improved without any anti-cancer drugs or steroids. She experienced recurrences of HPS at 15 mon and 21 mon after first presentation, but lymphoma cells were not observed. Relapse of IVLBCL with pulmonary involvement occurred 27 mon after first presentation. She underwent R-CHOP therapy followed by autologous stem cell transplantation. She is currently alive and without lymphoma. Immunostaining by anti-ssDNA suggested that spontaneous regression may have been due to apoptosis of the lymphoma cells.

摘要

一名61岁的日本女性出现噬血细胞综合征（HPS），并患有血管内大B细胞淋巴瘤（IVLBCL）。经过几天的支持治疗，她的病情在未使用任何抗癌药物或类固醇的情况下有所改善。首次出现症状后15个月和21个月时，她经历了HPS复发，但未观察到淋巴瘤细胞。首次出现症状后27个月，IVLBCL伴肺部受累复发。她接受了R-CHOP治疗，随后进行了自体干细胞移植。她目前还活着，且没有淋巴瘤。抗单链DNA免疫染色表明，自发缓解可能是由于淋巴瘤细胞凋亡所致。