Chai Zhihua, Ma Liya, Wang Yanxia, Ren Xuejun
a Department of Environmental Engineering , North China Institute of Science and Technology , Beijing , P.R. China.
b Department of Chemical Engineering , Chengde Petroleum College , Chengde , P.R. China.
J Biomater Sci Polym Ed. 2016;27(7):599-610. doi: 10.1080/09205063.2016.1140503. Epub 2016 Mar 9.
An amphiphilic glycopolymer, poly(D-gluconamidoethyl methacrylate -r-3-methacrylamido phenylboronic acid), which could self-assemble to form nanoparticles with a narrow size distribution, was synthesized. Transmission electron microscopy showed that the nanoparticles were spherical in shape with diameters of about 120 nm. The phenylboronic acid rendered the glycopolymer nanoparticles glucose sensitive, which was evident from swelling behavior of the nanoparticles at different glucose concentrations and was found to be dependent on the glucose level. Insulin was efficiently encapsulated within the nanoparticles (up to 15%), and the release of insulin increased with an increase in the level of glucose in the medium. Cell viability tests proved that the glycopolymer nanoparticles had good cytocompatibility, due to which the glycopolymers have the potential to be used in biomedical fields.
合成了一种两亲性糖聚合物，聚（甲基丙烯酸 D - 葡糖酰胺基乙酯 -r-3-甲基丙烯酰胺基苯硼酸），它能自组装形成尺寸分布窄的纳米颗粒。透射电子显微镜显示纳米颗粒呈球形，直径约为120纳米。苯硼酸使糖聚合物纳米颗粒对葡萄糖敏感，这从纳米颗粒在不同葡萄糖浓度下的溶胀行为中明显可见，且发现其依赖于葡萄糖水平。胰岛素被有效地包封在纳米颗粒内（高达15%），并且胰岛素的释放随着培养基中葡萄糖水平的升高而增加。细胞活力测试证明糖聚合物纳米颗粒具有良好的细胞相容性，因此这种糖聚合物有潜力用于生物医学领域。
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