早产儿的骨骼状况：不同营养方案的影响及骨病的潜在标志物
Bone status in preterm infant: influences of different nutritional regimens and possible markers of bone disease.
作者信息
Meneghelli M, Pasinato A, Salvadori S, Gaio P, Fantinato M, Vanzo V, De Terlizzi F, Verlato G
机构信息
Neonatal Intensive Care Unit, Women's and Children's Health Department, University Hospital of Padova, Padova, Italy.
Laboratory of Clinical Biophysics, IGEA, Modena, Italy.
出版信息
J Perinatol. 2016 May;36(5):394-400. doi: 10.1038/jp.2015.212. Epub 2016 Jan 14.
OBJECTIVE
The objective of this study was to evaluate possible influences of parenteral nutrition on growth and bone development in preterms and to search for markers of bone status.
STUDY DESIGN
Metacarpus bone transmission time (mc-BTT) was performed at birth, 21 days and 36 weeks of gestational age (GA) in preterms, receiving two different nutritional regimens, together with biochemical analysis.
RESULT
A total of 234 patients were studied. Newborns with aggressive nutrition had significantly better growth rate and higher values of mc-BTT until discharge. Mc-BTT at day 21 correlates positively with nutritional intakes and phosphatemia; lower limb length positively correlated with mc-BTT (P<0.01). Newborns with low energy intake in the first week of life (<70 kcal kg(-1) per day) and low serum phosphate level (<1.4 mmol l(-1)) at 21 days had lower mc-BTT at 36 weeks of GA (P<0.01).
CONCLUSION
Aggressive parenteral intakes in preterms improve growth and bone status in the short-medium term, suggesting that early nutrition could influence bone development.
目的
本研究的目的是评估肠外营养对早产儿生长和骨骼发育的可能影响，并寻找骨状态标志物。
研究设计
对接受两种不同营养方案的早产儿在出生时、出生后21天和孕龄（GA）36周时进行掌骨骨传导时间（mc-BTT）测定，并进行生化分析。
结果
共研究了234例患者。接受积极营养的新生儿在出院前生长速度明显更好，mc-BTT值更高。出生后21天的mc-BTT与营养摄入量和血磷水平呈正相关；下肢长度与mc-BTT呈正相关（P<0.01）。出生后第一周能量摄入低（<70千卡·千克⁻¹/天）且出生后21天血清磷水平低（<1.4毫摩尔/升）的新生儿在孕龄36周时mc-BTT较低（P<0.01）。
结论
早产儿积极的肠外营养摄入在中短期内可改善生长和骨状态，提示早期营养可能影响骨骼发育。
Zotero 插件