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[食管裂孔疝和胃食管反流病的手术治疗,nissen术式还是Toupet术式?]

[Surgery of the hiatal hernia and gastroesophageal reflux dinase, Nissen or Toupet?].

作者信息

Kasalický M, Koblihová E

出版信息

Rozhl Chir. 2015 Dec;94(12):510-5.

Abstract

INTRODUCTION

In 2016 60 years will have elapsed from the first publication by Nissen about his surgical method of 360° fundoplication around distal esophagus and its final effect. Nissens fundoplication is currently the most common surgical method for the gastroesophageal reflux (GER) and hiatal hernia (HH) probably. Incidence of HH ranges between 25-50% in the western population. Current prevalence of GER ranges between 4-10% in Europe and 5-7% in North America, but some studies report even 10-20%.

METHODS

From 2010 to 2015, 157 laparoscopic procedures for HH or gastroesophageal reflux disease (GERD) were done at the Department of Surgery, the Second Faculty of Medicine, Charles University and Central Military Hospital in Prague. Most of the patients were operated because of symptomatic HH with/without GERD. Only very few patients were operated only for GERD without HH. The group of the patients included 73 men and 84 women with the mean age 53.9 years in the range 20-88 years. 11 patients of the group were operated because of the upside-down stomach syndrome. 109 (69.4%) patients underwent Nissens 360° fundoplication (NFP) and 48 (30.6%) patients underwent Toupets 270° fundoplication (TFP). The patients were followed after 3 month, 6 month, 12 month and then once a year after the surgery. Symptoms such as heartburn, dysphagia, belching, bloating or recurrence of HH or GERD were collected prospectively and analyzed retrospectively. Methods of descriptive statistics and explorative unidirectional analysis were used.

RESULTS

From 2010 to 2015, 157 laparoscopic procedures were done for HH or GERD. No death occurred in the group of the patients in connection with the surgery. Similar rates of considerable improvement or resolution of the symptoms such as the reflux, heartburn, and epigastric pain were observed after three months from the surgery among patients after NFP or TFP. Postoperative dysphagia resolved in 4-7 weeks in the group after NFP, and in 3-5 weeks in the group after TFP. Disease recurrence was observed in 36 (22.9%) patients in 2 to 5 years after the surgery. Recurrence of only the gastroesophageal reflux without HH was observed in 22 patients (14 after NFP; 8 after TFP), shown by endoscopy or x-ray assessment, with a satisfactory response to PPI medication. Laparoscopic rehiatoplasty and refundoplication according to Nissen were performed in 14 patients with HH recurrence with/without the reflux (8 after NFP; 6 after TFP).

CONCLUSION

Laparoscopic antireflux surgery of GERD and HH is safe and is associated with very low perioperative morbidity and minimal morbidity. Both NFP and TFP have a similar effect on restoration of the mechanical gastroesophageal barrier against gastric reflux, with significant effect on resolution of GERD and HH symptoms and with a marked improvement of the patients quality of life. As regards morbid obese patients, weight reduction is needed before the surgery. Hiatoplasty done at the same time with the bariatric procedure is recommended in morbid obese patients with HH indicated for the bariatric-metabolic surgery.

摘要

引言

自尼森首次发表关于其围绕食管远端进行360°胃底折叠术及其最终效果的手术方法以来,已过去60年。尼森胃底折叠术目前可能是治疗胃食管反流(GER)和食管裂孔疝(HH)最常用的手术方法。在西方人群中,HH的发病率在25%至50%之间。目前,GER在欧洲的患病率在4%至10%之间,在北美为5%至7%,但一些研究报告甚至高达10%至20%。

方法

2010年至2015年期间,布拉格查理大学第二医学院和中央军事医院外科进行了157例针对HH或胃食管反流病(GERD)的腹腔镜手术。大多数患者因有症状的HH伴/不伴GERD而接受手术。仅有极少数患者仅因GERD而无HH接受手术。该组患者包括73名男性和84名女性,平均年龄53.9岁,年龄范围在20至88岁之间。该组中有11名患者因胃翻转综合征接受手术。109例(69.4%)患者接受了尼森360°胃底折叠术(NFP),48例(30.6%)患者接受了图佩270°胃底折叠术(TFP)。术后3个月、6个月、12个月进行随访,之后每年随访一次。前瞻性收集烧心、吞咽困难、嗳气、腹胀或HH或GERD复发等症状,并进行回顾性分析。采用描述性统计方法和探索性单向分析方法。

结果

2010年至2015年期间,针对HH或GERD进行了157例腹腔镜手术。该组患者中无手术相关死亡病例。NFP或TFP术后3个月,观察到反流、烧心和上腹部疼痛等症状有相当程度改善或缓解的比例相似。NFP组术后吞咽困难在4至7周内缓解,TFP组在3至5周内缓解。术后2至5年,36例(22.9%)患者出现疾病复发。经内镜或X线评估,22例患者仅出现无HH的胃食管反流复发(NFP术后14例;TFP术后8例),对质子泵抑制剂治疗反应良好。14例HH复发伴/不伴反流的患者(NFP术后8例;TFP术后6例)接受了腹腔镜食管裂孔成形术及尼森式胃底折叠术。

结论

GERD和HH的腹腔镜抗反流手术是安全的,围手术期发病率极低,并发症极少。NFP和TFP在恢复胃食管机械性抗反流屏障方面效果相似,对GERD和HH症状的缓解有显著效果,患者生活质量明显改善。对于病态肥胖患者,术前需要减重。对于适合进行减重代谢手术的HH病态肥胖患者,建议在进行减重手术的同时行食管裂孔成形术。

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