School of Medicine and Medical Science & The Conway Institute, University College Dublin, Belfield, Dublin 4, Ireland.
School of Medicine and Medical Science & The Conway Institute, University College Dublin, Belfield, Dublin 4, Ireland.
Mol Aspects Med. 2016 Feb-Mar;47-48:24-34. doi: 10.1016/j.mam.2015.12.004. Epub 2016 Jan 6.
Uncontrolled or non-resolving inflammation underpins a range of disease states including rheumatoid arthritis, inflammatory bowel disease and atherosclerosis. Hypoxia is a prominent feature of chronically inflamed tissues. This is due to elevated oxygen consumption by highly metabolically active inflamed resident cells and activated infiltrating immunocytes, as well as diminished oxygen supply due to vascular dysfunction. Tissue hypoxia can have a significant impact upon inflammatory signaling pathways in immune and non-immune cells and this can impact upon disease progression. In this review, we will discuss the relationship between tissue hypoxia and inflammation and identify how hypoxia-sensitive signaling pathways are potential therapeutic targets in chronic inflammatory disease.
失控或无法解决的炎症是一系列疾病状态的基础，包括类风湿性关节炎、炎症性肠病和动脉粥样硬化。缺氧是慢性炎症组织的一个突出特征。这是由于高度代谢活跃的炎症常驻细胞和激活的浸润免疫细胞的耗氧量增加，以及由于血管功能障碍导致的氧供应减少。组织缺氧会对免疫和非免疫细胞中的炎症信号通路产生重大影响，从而影响疾病的进展。在这篇综述中，我们将讨论组织缺氧与炎症之间的关系，并确定缺氧敏感信号通路如何成为慢性炎症性疾病的潜在治疗靶点。
