合成大麻素3-苄基-5-[1-(2-吡咯烷-1-基乙基)-1H-吲哚-3-基]-1,2,4-恶二唑。新型精神活性物质在非法市场的首次发现。
Synthetic cannabinoid 3-benzyl-5-[1-(2-pyrrolidin-1-ylethyl)-1H-indol-3-yl]-1,2,4-oxadiazole. The first detection in illicit market of new psychoactive substances.
作者信息
Shevyrin Vadim, Melkozerov Vladimir, Eltsov Oleg, Shafran Yuri, Morzherin Yuri
机构信息
Ural Federal University, Institute of Chemical Technology, 19 Mira Street, 620002 Ekaterinburg, Russian Federation.
Expert and Criminalistic Center, Main Agency of the Ministry of the Interior of the Russian Federation, Sverdlovsk Region Branch, 17 Lenina Avenue, 620014 Ekaterinburg, Russian Federation.
出版信息
Forensic Sci Int. 2016 Feb;259:95-100. doi: 10.1016/j.forsciint.2015.12.019. Epub 2015 Dec 21.
We were the first to detect 3-benzyl-5-[1-(2-pyrrolidin-1-ylethyl)-1H-indol-3-yl]-1,2,4-oxadiazole (given name BzODZ-EPyr) as a new synthetic cannabinoid, in illegal market of new psychoactive compounds (NPS). The compound was known only from pharmaceutical literature so far. BzODZ-EPyr was identified by means of gas chromatography/mass spectrometry (GC/MS) including high resolution mass spectrometry (GC/HRMS), ultra-high performance liquid chromatography/high resolution tandem mass spectrometry (UHPLC/HRMS(2)), Fourier-transform infrared spectroscopy (FT-IR) and nuclear magnetic resonance spectroscopy (NMR) (1)H and (13)C. The peculiarities of mass-spectral fragmentation in experiments in electronic ionization (EI) and collision-induced dissociation (CID) modes were studied. Herewith we report analytical characteristics of BzODZ-EPyr enabling its (and possible analogues thereof) determination in criminal seizures.
我们首次在新型精神活性物质（NPS）非法市场中检测到3-苄基-5-[1-(2-吡咯烷-1-基乙基)-1H-吲哚-3-基]-1,2,4-恶二唑（命名为BzODZ-EPyr），这是一种新型合成大麻素。到目前为止，该化合物仅在药学文献中有所记载。通过气相色谱/质谱联用仪（GC/MS），包括高分辨率质谱（GC/HRMS）、超高效液相色谱/高分辨率串联质谱（UHPLC/HRMS(2)）、傅里叶变换红外光谱（FT-IR）以及核磁共振光谱（NMR）的氢谱（¹H）和碳谱（¹³C）对BzODZ-EPyr进行了鉴定。研究了在电子电离（EI）和碰撞诱导解离（CID）模式实验中质谱碎片的特点。在此，我们报告了BzODZ-EPyr的分析特性，以便能够在刑事扣押物中对其（及其可能的类似物）进行测定。
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