Larsen Inge, Nielsen Søren Saxmose, Olsen John Elmerdahl, Nielsen Jens Peter
University of Copenhagen, Faculty of Health and Medical Sciences, Department of Large Animal Sciences, Grønnegårdsvej 2, 1870 Frederiksberg C, Denmark.
University of Copenhagen, Faculty of Health and Medical Sciences, Department of Large Animal Sciences, Grønnegårdsvej 2, 1870 Frederiksberg C, Denmark.
Prev Vet Med. 2016 Feb 1;124:25-33. doi: 10.1016/j.prevetmed.2015.12.018. Epub 2015 Dec 30.
Antimicrobial consumption in animal husbandry is of great scientific and political concern due to the risk of selection of resistant bacteria. Whilst a reduction in the use of antimicrobials is therefore preferable, the efficacy of treatment must be maintained in order to ensure animal welfare and profitability of pig production. The objective of this study was to evaluate the efficacy of three treatment strategies under field conditions against Lawsonia intracellularis (LI)-related diarrhoea. A randomised clinical trial was carried out in four Danish pig herds, including a total of 520 pigs from 36 nursery batches. A high prevalence of LI was demonstrated in all herds prior to the initiation of the study. Treatment efficacy was assessed by faecal shedding of LI, the occurrence of diarrhoea and average daily weight gain (ADG) after treatment. All strategies were implemented at batch level at presence of LI-related diarrhoea and included daily treatment with 10mg oxytetracycline (OTC) per kilogram of bodyweight for 5 days, though the OTC was administered differently: either by oral treatment of all pigs in a batch, by oral treatment of pigs in diarrhoeic pens only, or by intramuscular treatment of individual diarrhoeic pigs only. The treatment strategies were randomly allocated to batches and were initiated at the presence of diarrhoea. From the included batches, 100% of the trial pigs were medicated in the batch treatment strategy, 87% in the pen treatment strategy and 55% in the individual treatment strategy. All strategies reduced the occurrence of diarrhoea and faecal shedding of LI after treatment. However, batch treatment was found to be most efficient in reducing both high-level LI shedding and diarrhoea when compared to the treatment of diarrhoeic pens or individual diarrhoeic pigs. There was no significant difference identified in ADG between the treatment strategies. In conclusion, batch treatment of all pigs in a section resulted in the highest efficacy for reducing diarrhoea and faecal shedding of LI.
由于存在筛选耐药菌的风险，畜牧业中的抗菌药物使用备受科学和政治关注。因此，减少抗菌药物的使用是更可取的，但必须维持治疗效果以确保动物福利和养猪生产的盈利能力。本研究的目的是在田间条件下评估三种治疗策略对胞内劳森菌（LI）相关腹泻的疗效。在丹麦的四个猪群中进行了一项随机临床试验，共纳入来自36个保育批次的520头猪。在研究开始前，所有猪群中LI的患病率都很高。通过治疗后LI的粪便排出情况、腹泻的发生情况和平均日增重（ADG）来评估治疗效果。所有策略均在出现LI相关腹泻时以批次为单位实施，包括每天每千克体重口服10毫克土霉素（OTC），持续5天，不过OTC的给药方式不同：要么对一批中的所有猪进行口服治疗，要么仅对腹泻栏中的猪进行口服治疗，要么仅对个体腹泻猪进行肌肉注射治疗。治疗策略随机分配给各个批次，并在出现腹泻时开始实施。在所纳入的批次中，批次治疗策略中有100%的试验猪用药，栏治疗策略中有87%的试验猪用药，个体治疗策略中有55%的试验猪用药。所有策略在治疗后都减少了腹泻的发生和LI的粪便排出。然而，与腹泻栏治疗或个体腹泻猪治疗相比，批次治疗在减少高水平LI排出和腹泻方面最为有效。各治疗策略之间的ADG没有显著差异。总之，对一个区域内的所有猪进行批次治疗在减少LI引起的腹泻和粪便排出方面效果最佳。
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