miRNA 调控的细胞因子信号通路和炎症反应关键成分在类风湿关节炎中的作用

miRNA-Regulated Key Components of Cytokine Signaling Pathways and Inflammation in Rheumatoid Arthritis.

机构信息

Institute for Skeletal Aging & Orthopedic Surgery, Chuncheon Sacred Heart Hospital, Hallym University, Chuncheon, 200704, Republic of Korea.

Department of Bioinformatics, School of Computer Sciences, Galgotias University, Greater Noida, 203201, Uttar Pradesh, India.

出版信息

Med Res Rev. 2016 May;36(3):425-39. doi: 10.1002/med.21384. Epub 2016 Jan 20.

DOI:10.1002/med.21384

PMID:26786912

Abstract

Rheumatoid arthritis (RA) is an inflammatory disease that primarily affects joints. This autoimmune disease pathogenesis is related to cytokine signaling. In this review, we have described the existence of various microRNAs (miRNAs) involved in regulation of major protein cascades of cytokine signaling associated with RA. Moreover, we have tried to portray the role of various miRNAs in different cytokines such as TNF-α, IL-1, IL-6, IL-10, IL-17, IL-18, IL-21, and granulocyte macrophage colony-stimulating factor (GMCSF). Along with this, we have also discussed the miRNA regulation in T cells and synovial tissue. From the analyzed data, we suggest that miR-146a and miR-155 might be the potential therapeutic target for treating RA. The insight illustrated in this review will offer a better understanding of the role of miRNA in cytokine signaling pathways and inflammation during RA and could project them as diagnostic or therapeutic agents in near future.

摘要

类风湿关节炎（RA）是一种主要影响关节的炎症性疾病。这种自身免疫性疾病的发病机制与细胞因子信号有关。在这篇综述中，我们描述了各种参与调节与 RA 相关的细胞因子信号主要蛋白级联的 microRNAs（miRNAs）的存在。此外，我们还试图描述各种 miRNAs 在不同细胞因子中的作用，如 TNF-α、IL-1、IL-6、IL-10、IL-17、IL-18、IL-21 和粒细胞-巨噬细胞集落刺激因子（GMCSF）。除此之外，我们还讨论了 T 细胞和滑膜组织中的 miRNA 调节。从分析的数据中，我们提出 miR-146a 和 miR-155 可能是治疗 RA 的潜在治疗靶点。本综述中阐述的观点将更好地理解 miRNA 在 RA 期间细胞因子信号通路和炎症中的作用，并可能将其作为未来的诊断或治疗剂。