Vogel R I, Austin G
Oral Surg Oral Med Oral Pathol. 1977 Jul;44(1):50-3. doi: 10.1016/0030-4220(77)90242-0.
Tetracycline, a broad-spectrum antibiotic, is known to cause intrinsic discoloration of the dentition. A case is being presented of extrinsic discoloration of the teeth associated with the use of this drug. This is believed to be the first such reported case in the literature. Possible mechanisms of how tetracycline may cause extrinsic tooth discoloration are discussed.
四环素是一种广谱抗生素,已知会导致牙列的内在变色。本文报告了一例与使用该药物相关的牙齿外源性变色病例。据信这是文献中首次报道的此类病例。文中讨论了四环素可能导致牙齿外源性变色的可能机制。