可卡因自我给药行为消退过程中发生的神经变化。
Neural Changes Developed during the Extinction of Cocaine Self-Administration Behavior.
作者信息
Higuera-Matas Alejandro, Miguens Miguel, Olmo Nuria Del, García-Lecumberri Carmen, Ambrosio Emilio
机构信息
Department of Psychobiology, School of Psychology, UNED, C/Juan del Rosal 10, 28040 Madrid, Spain.
Department of Basic Psychology I, School of Psychology, UNED, C/Juan del Rosal 10, 28040 Madrid, Spain.
出版信息
Pharmaceuticals (Basel). 2011 Oct 13;4(10):1315-27. doi: 10.3390/ph4101315.
The high rate of recidivism in cocaine addiction after prolonged periods of abstinence poses a significant problem for the effective treatment of this condition. Moreover, the neurobiological basis of this relapse phenomenon remains poorly understood. In this review, we will discuss the evidence currently available regarding the neurobiological changes during the extinction of cocaine self-administration. Specifically, we will focus on alterations in the dopaminergic, opioidergic, glutamatergic, cholinergic, serotoninergic and CRF systems described in self-administration experiments and extinction studies after chronic cocaine administration. We will also discuss the differences related to contingent versus non-contingent cocaine administration, which highlights the importance of environmental cues on drug effects and extinction. The findings discussed in this review may aid the development of more effective therapeutic approaches to treat cocaine relapse.
长期禁欲后可卡因成瘾的高复发率给这种疾病的有效治疗带来了重大问题。此外，这种复发现象的神经生物学基础仍知之甚少。在本综述中，我们将讨论目前关于可卡因自我给药消退过程中神经生物学变化的现有证据。具体而言，我们将重点关注慢性可卡因给药后自我给药实验和消退研究中描述的多巴胺能、阿片样物质能、谷氨酸能、胆碱能、5-羟色胺能和促肾上腺皮质激素释放因子（CRF）系统的变化。我们还将讨论与偶然性与非偶然性可卡因给药相关的差异，这突出了环境线索对药物作用和消退的重要性。本综述中讨论的研究结果可能有助于开发更有效的治疗可卡因复发的方法。
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