Kao Shyan-Yuan, Soares Vitor Y R, Kristiansen Arthur G, Stankovic Konstantina M
Eaton Peabody Laboratories and Department of Otolaryngology, Massachusetts Eye and Ear Infirmary, Boston, MA, USA.
Department of Otology and Laryngology, Harvard Medical School, Boston, MA, USA.
Aging Cell. 2016 Apr;15(2):301-8. doi: 10.1111/acel.12437. Epub 2016 Jan 21.
Tumor necrosis factor (TNF) family cytokines are important mediators of inflammation. Elevated levels of serum TNF-α are associated with human sensorineural hearing loss via poorly understood mechanisms. We demonstrate, for the first time, expression of TNF-related apoptosis-inducing ligand (TRAIL) and its signaling death receptor 5 (DR5) in the murine inner ear and show that exogenous TRAIL can trigger hair cell and neuronal degeneration, which can be partly prevented with DR5-blocking antibodies.
肿瘤坏死因子（TNF）家族细胞因子是炎症的重要介质。血清TNF-α水平升高通过尚不清楚的机制与人类感音神经性听力损失相关。我们首次证明了TNF相关凋亡诱导配体（TRAIL）及其信号传导死亡受体5（DR5）在小鼠内耳中的表达，并表明外源性TRAIL可引发毛细胞和神经元变性，而DR5阻断抗体可部分预防这种变性。
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