Răschip Irina Elena, Panainte Alina Diana, Pamfil Daniela, Profire Lenuta, Vasile Cornelia
Rev Med Chir Soc Med Nat Iasi. 2015 Oct-Dec;119(4):1189-94.
To develop sustained release matrix tablets based on xanthan as highly water-soluble, cost-effective, non-toxic, easily available, and suitable hydrophilic systems.
Xanthan and lignin epoxy-modified resin (LER) mixture were crosslinked using epichlorohydrin as crosslinking agent leading to superabsorbent hydrogels with high swelling rate in aqueous mediums.
These hydrogels were tested as carries by the loading/delivery behaviour of bisoprolol fumarate in physiological conditions and based on the obtained results these hydrogels may show interest for application in medical and pharmaceutical areas. The amount of drug loaded in polymer networks was found to be ranging between 14.4% and 19.2%. Drug release was retarded and the release mechanism of the active principle was found to depend on matrix composition.
开发基于黄原胶的缓释基质片剂，黄原胶是高度水溶性、成本效益高、无毒、易于获取且合适的亲水性体系。
使用环氧氯丙烷作为交联剂，将黄原胶和木质素环氧改性树脂（LER）混合物进行交联，得到在水性介质中具有高溶胀率的超吸水性水凝胶。
通过富马酸比索洛尔在生理条件下的负载/释放行为对这些水凝胶作为载体进行了测试，基于所得结果，这些水凝胶可能在医学和制药领域具有应用价值。发现聚合物网络中负载的药物量在14.4%至19.2%之间。药物释放受到延迟，且发现活性成分的释放机制取决于基质组成。
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