Pevni Dmitry, Mohr Rephael, Paz Yosef, Kramer Amir, Ben-Gal Yanai, Nesher Nahum, Medalion Benjamin
Department of Cardiothoracic Surgery, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel; Department of Cardiothoracic Surgery, Rabin Medical Center, Petah Tikva, Tel Aviv, Israel.
Department of Cardiothoracic Surgery, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel; Department of Cardiothoracic Surgery, Rabin Medical Center, Petah Tikva, Tel Aviv, Israel.
J Thorac Cardiovasc Surg. 2016 May;151(5):1311-9. doi: 10.1016/j.jtcvs.2015.12.005. Epub 2015 Dec 12.
Bilateral internal mammary artery (BIMA) grafting is associated with improved survival. However, many surgeons are reluctant to use this technique, owing to the potentially increased risk of sternal infection. The composite T-graft with radial artery (RA) attached end-to-side to the left internal mammary artery (IMA) provides complete arterial revascularization without increased risk of sternal infection. The purpose of this study is to compare outcomes of these 2 strategies.
Patients who underwent BIMA grafting using the composite T-graft technique, between 1996 and 2010 (n = 1329), were compared with 389 patients who underwent composite grafting with a single IMA + RA during the same time period.
Patients undergoing single IMA grafting were older, more often women, and more likely to have diabetes, peripheral vascular disease, and COPD, and to need an emergency operation. Congestive heart failure, left main disease, and recent myocardial infarction were more prevalent with bilateral grafting. Propensity-score matching was used to account for differences between groups in preoperative patient characteristics. The 268 matched pairs had similar characteristics. The median follow-up time was 14.19 (95% confidence interval 13.43-14.95) years. Operative mortality and Kaplan-Meier 10-year survival of the 2 matched groups were similar (3.4% vs 3.7%, and 61.6% vs 64%, for the groups treated with BIMA and single IMA, respectively). Cox-adjusted survival was similar (P = .514). Age, chronic renal failure, and performance of <3 bypass grafts were independent predictors of decreased survival.
This study suggests that long-term outcomes of arterial revascularization with a composite T-graft constructed using left IMA and RA are not inferior to outcomes after BIMA grafting.
双侧乳内动脉(BIMA)移植与生存率提高相关。然而,许多外科医生不愿使用该技术,因为胸骨感染风险可能增加。将桡动脉(RA)端侧连接至左乳内动脉(IMA)的复合T形移植物可实现完全动脉血运重建,且不会增加胸骨感染风险。本研究的目的是比较这两种策略的结果。
将1996年至2010年间采用复合T形移植物技术进行BIMA移植的患者(n = 1329)与同期进行单根IMA + RA复合移植的389例患者进行比较。
接受单根IMA移植的患者年龄更大,女性更多,更常患有糖尿病、外周血管疾病和慢性阻塞性肺疾病(COPD),且更需要急诊手术。充血性心力衰竭、左主干病变和近期心肌梗死在双侧移植中更为常见。采用倾向评分匹配法来考虑两组术前患者特征的差异。268对匹配对具有相似特征。中位随访时间为14.19(95%置信区间13.43 - 14.95)年。两组匹配组的手术死亡率和Kaplan-Meier 10年生存率相似(BIMA组和单根IMA组分别为3.4%对3.7%,61.6%对64%)。Cox调整后的生存率相似(P = 0.514)。年龄、慢性肾衰竭以及旁路移植术少于3处是生存率降低的独立预测因素。
本研究表明,使用左IMA和RA构建的复合T形移植物进行动脉血运重建的长期结果并不逊于BIMA移植后的结果。