Cheong Sun Hee, Yang Hye-Won, Ko Eun-Yi, Ahn Ginnae, Lee WonWoo, Kim Daekyung, Jeon You-Jin, Kim Kil-Nam
Department of Marine Bio Food Science, College of Fisheries and Ocean Science, Chonnam National University, Yeosu 550-749, South Korea.
School of Marine Biomedical Sciences, Jeju National University, Jeju 690-756, South Korea.
Fish Shellfish Immunol. 2016 Mar;50:16-20. doi: 10.1016/j.fsi.2016.01.018. Epub 2016 Jan 18.
In this study, trans-1,3-diphenyl-2,3-epoxypropane-1-one (DPEP) was evaluated for its anti-inflammatory activity in lipopolysaccharide (LPS)-stimulated zebrafish embryos. In the present study, DPEP exhibited potential protective effect in the zebrafish embryos as confirmed by survival rate. DPEP acts as an effective agent against reactive oxygen species (ROS) formation induced by LPS. Moreover, DPEP effectively inhibited LPS-induced nitric oxide (NO) production in zebrafish embryos. In addition, DPEP significantly reduced the expression of inducible NOS (iNOS) and cycloxygenase 2 (COX-2), which generate NO as a key mediator of inflammation in a concentration-dependent manner. According to these results, DPEP could be considered an effective anti-inflammatory agent, which might be further developed as a functional ingredient. This is the first report of the anti-inflammatory activity of DPEP in the LPS-stimulated zebrafish model.
在本研究中，对反式-1,3-二苯基-2,3-环氧丙烷-1-酮（DPEP）在脂多糖（LPS）刺激的斑马鱼胚胎中的抗炎活性进行了评估。在本研究中，如存活率所证实的，DPEP在斑马鱼胚胎中表现出潜在的保护作用。DPEP作为一种有效试剂可对抗由LPS诱导的活性氧（ROS）形成。此外，DPEP有效抑制斑马鱼胚胎中LPS诱导的一氧化氮（NO）产生。另外，DPEP显著降低诱导型一氧化氮合酶（iNOS）和环氧化酶2（COX-2）的表达，它们以浓度依赖的方式产生NO作为炎症的关键介质。根据这些结果，DPEP可被认为是一种有效的抗炎剂，可能会进一步开发成为一种功能性成分。这是关于DPEP在LPS刺激的斑马鱼模型中的抗炎活性的首次报道。
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