MHY384通过抑制一氧化氮诱导的环鸟苷酸信号传导发挥抗黑色素生成活性。 - Suppr

Antimelanogenic activity of MHY384 via inhibition of NO-induced cGMP signalling.

作者信息

Moon Kyoung Mi, Jeong Ji Won, Lee Bonggi, Kim Dae Hyun, Kim Hye Rim, Woo Young Woo, Lee Eun Kyeong, An Hye Jin, Kim Min Jo, Choi Yeon Ja, Son Su Jin, Chun Pusoon, Moon Hyung Ryong, Chung Hae Young

机构信息

Molecular Inflammation Research Center for Aging Intervention (MRCA), College of Pharmacy, Pusan National University, Busan, Korea.

Laboratory of Medicinal Chemistry, College of Pharmacy, Pusan National University, Busan, Korea.

出版信息

Exp Dermatol. 2016 Aug;25(8):652-4. doi: 10.1111/exd.12953. Epub 2016 Feb 26.

DOI:10.1111/exd.12953

PMID:26799796

Abstract

摘要

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Antimelanogenic activity of MHY384 via inhibition of NO-induced cGMP signalling.MHY384通过抑制一氧化氮诱导的环鸟苷酸信号传导发挥抗黑色素生成活性。

Exp Dermatol. 2016 Aug;25(8):652-4. doi: 10.1111/exd.12953. Epub 2016 Feb 26.

Suppression of melanogenesis by a newly synthesized compound, MHY966 via the nitric oxide/protein kinase G signaling pathway in murine skin.新型化合物 MHY966 通过一氧化氮/蛋白激酶 G 信号通路抑制小鼠皮肤黑色素生成。

J Dermatol Sci. 2012 Dec;68(3):164-71. doi: 10.1016/j.jdermsci.2012.09.014. Epub 2012 Oct 3.

Characterization of a small molecule inhibitor of melanogenesis that inhibits tyrosinase activity and scavenges nitric oxide (NO).一种抑制黑色素生成的小分子抑制剂的特性，该抑制剂可抑制酪氨酸酶活性并清除一氧化氮（NO）。

Biochim Biophys Acta. 2013 Oct;1830(10):4752-61. doi: 10.1016/j.bbagen.2013.06.002. Epub 2013 Jun 12.

Characterization of a novel tyrosinase inhibitor, (2RS,4R)-2-(2,4-dihydroxyphenyl)thiazolidine-4-carboxylic acid (MHY384).新型酪氨酸酶抑制剂（2RS,4R）-2-（2,4-二羟基苯基）噻唑烷-4-羧酸（MHY384）的特性研究

Biochim Biophys Acta. 2012 Apr;1820(4):542-9. doi: 10.1016/j.bbagen.2012.01.001. Epub 2012 Jan 9.

Inhibition of UVA-mediated melanogenesis by ascorbic acid through modulation of antioxidant defense and nitric oxide system.抗坏血酸通过调节抗氧化防御和一氧化氮系统抑制 UVA 介导的黑色素生成。

Arch Pharm Res. 2011 May;34(5):811-20. doi: 10.1007/s12272-011-0515-3. Epub 2011 Jun 9.

Anti-melanogenic effects of Aster spathulifolius extract in UVB-exposed C57BL/6J mice and B16F10 melanoma cells through the regulation of MAPK/ERK and AKT/GSK3β signalling.匙叶紫菀提取物通过调节MAPK/ERK和AKT/GSK3β信号通路对紫外线B照射的C57BL/6J小鼠和B16F10黑色素瘤细胞的抗黑色素生成作用

J Pharm Pharmacol. 2016 Apr;68(4):503-13. doi: 10.1111/jphp.12524. Epub 2016 Mar 19.

Discovery of new depigmenting compounds and their efficacy to treat hyperpigmentation: Evidence from in vitro study.发现新的脱色化合物及其治疗色素沉着过度的功效：来自体外研究的证据。

J Cosmet Dermatol. 2019 Jun;18(3):703-727. doi: 10.1111/jocd.12900. Epub 2019 Mar 13.

The depigmenting effect of natural resorcinol type polyphenols Kuwanon O and Sanggenon T from the roots of morus australis.来自鸡桑根的天然间苯二酚型多酚类化合物桑根酮O和桑根酮T的色素脱除作用。

J Ethnopharmacol. 2017 Jan 4;195:196-203. doi: 10.1016/j.jep.2016.11.019. Epub 2016 Nov 13.

Novel Anti-Melanogenesis Properties of Polydeoxyribonucleotide, a Popular Wound Healing Booster.聚脱氧核糖核苷酸的新型抗黑色素生成特性，一种常用的伤口愈合促进剂。

Int J Mol Sci. 2016 Sep 1;17(9):1448. doi: 10.3390/ijms17091448.

Involvement of the nitric oxide-cyclic GMP pathway and neuronal nitric oxide synthase in ATP-induced Ca2+ signalling in cochlear inner hair cells.一氧化氮 - 环磷酸鸟苷途径及神经元型一氧化氮合酶在三磷酸腺苷诱导的耳蜗内毛细胞钙离子信号传导中的作用

Eur J Neurosci. 2005 Jun;21(11):2912-22. doi: 10.1111/j.1460-9568.2005.04135.x.

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Catechin-7--α-L-rhamnopyranoside can reduce α-MSH-induced melanogenesis in B16F10 melanoma cells through competitive inhibition of tyrosinase.表儿茶素-7--α-L-鼠李糖苷通过竞争性抑制酪氨酸酶减少 α-MSH 诱导的 B16F10 黑素瘤细胞中的黑素生成。

Int J Med Sci. 2022 Jun 27;19(7):1131-1137. doi: 10.7150/ijms.72241. eCollection 2022.

Design, synthesis, and antimelanogenic effects of (2-substituted phenyl-1,3-dithiolan-4-yl)methanol derivatives.（2-取代苯基-1,3-二硫杂环戊烷-4-基）甲醇衍生物的设计、合成及抗黑色素生成作用

Drug Des Devel Ther. 2017 Mar 16;11:827-836. doi: 10.2147/DDDT.S131538. eCollection 2017.

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Antimelanogenic activity of MHY384 via inhibition of NO-induced cGMP signalling.

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