Alotaibi Ohoud, Al-Zaher Nabil, Alotaibi Faiza, Khoja Hatim, Qannam Ahmed
Department of Oral Medicine and Diagnostic Sciences, College of Dentistry, King Saud University, Riyadh, Saudi Arabia.
Department of Otolaryngology, Head and Neck Surgery, King Faisal Specialist Hospital & Research Centre, Riyadh, Saudi Arabia.
Hematol Oncol Stem Cell Ther. 2016 Sep;9(3):118-22. doi: 10.1016/j.hemonc.2015.12.005. Epub 2016 Jan 16.
Primary intraosseous squamous cell carcinoma (PIOSCC) is a rare malignant neoplasm that has an exquisitely exclusive affection to the jawbone. It is defined as squamous cell carcinoma arising within the jaw and developing from residual odontogenic epithelium or from a preexisting odontogenic cyst or tumor. The solid-type of this tumor is a central jaw carcinoma arising de novo and has no initial connection with the oral mucosa. Herein, we report a case of solid-type PIOSCC involving the mandible in a 37-year-old male patient elucidating its histopathological and imaging findings. The patient underwent surgical resection followed by post-operative adjuvant radiotherapy. The close 2-year follow up of the patient revealed neither locoregional nor distant metastasis.
原发性骨内鳞状细胞癌(PIOSCC)是一种罕见的恶性肿瘤,它对颌骨有着极为独特的侵害。它被定义为起源于颌骨内、由残留牙源性上皮或先前存在的牙源性囊肿或肿瘤发展而来的鳞状细胞癌。这种肿瘤的实性类型是一种原发性中央颌骨癌,最初与口腔黏膜没有联系。在此,我们报告一例37岁男性患者发生的累及下颌骨的实性型PIOSCC病例,阐述其组织病理学和影像学表现。患者接受了手术切除,随后进行术后辅助放疗。对患者进行的为期2年的密切随访显示既无局部区域转移也无远处转移。