慢性前葡萄膜炎患儿青光眼滤过术后炎症活动的变化
Changes in Inflammatory Activity after Glaucoma Filtration Surgery in Children with Chronic Anterior Uveitis.
作者信息
Wiese Christina, Heiligenhaus Arnd, Heinz Carsten
机构信息
a Department of Ophthalmology , St. Franziskus-Hospital Muenster , Germany.
b Department of Ophthalmology at University of Duisburg-Essen , Germany.
出版信息
Ocul Immunol Inflamm. 2016 Aug;24(4):397-401. doi: 10.3109/09273948.2015.1088041. Epub 2016 Jan 25.
PURPOSE
To evaluate changes in inflammatory activity over time in patients with juvenile idiopathic arthritis (JIA)-associated anterior uveitis after two different types of glaucoma surgery.
METHODS
Retrospective analysis of 32 patients with JIA who had trabeculectomy (TE, 21 eyes) or Ahmed glaucoma valve implantation (AGV, 11 eyes). Inflammatory activity and use of anti-inflammatory medication were evaluated 1 year prior to surgery and in the first, third, and fifth years after surgery.
RESULTS
In both groups IOP decreased significantly from pre-surgery to 2 years after surgery (TE, 31.1 ± 6.7 to 12.8 ± 6.1 mmHg, p<0.0001; AGV, 28.5 ± 8.5 to 14.9 ± 6.6 mmHg, p<0.001). In the TE group flare, anterior chamber cells, and uveitis activity decreased significantly after surgery, whereas with AGV there was no sustained reduction of flare.
CONCLUSIONS
The degree of inflammation in JIA-associated uveitis is significantly reduced after trabeculectomy.
目的
评估两种不同类型的青光眼手术后，幼年特发性关节炎（JIA）相关前葡萄膜炎患者炎症活动随时间的变化。
方法
对32例行小梁切除术（TE，21只眼）或艾哈迈德青光眼引流阀植入术（AGV，11只眼）的JIA患者进行回顾性分析。在手术前1年以及手术后第1年、第3年和第5年评估炎症活动和抗炎药物的使用情况。
结果
两组患者的眼压从术前到术后2年均显著降低（TE组，从31.1±6.7 mmHg降至12.8±6.1 mmHg，p<0.0001；AGV组，从28.5±8.5 mmHg降至14.9±6.6 mmHg，p<0.001）。在TE组，手术后闪光感、前房细胞和葡萄膜炎活动度显著降低，而AGV组闪光感没有持续减轻。
结论
小梁切除术后JIA相关葡萄膜炎的炎症程度显著降低。
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