鼻内局部应用雌激素治疗遗传性出血性毛细血管扩张症鼻出血
Intranasal topical estrogen in the management of epistaxis in hereditary hemorrhagic telangiectasia.
作者信息
Minami Kazuhiko, Haji Tomoyuki
机构信息
a Department of Head and Neck Surgery , Saitama Medical University International Medical Center , Hidaka , Saitama , Japan ;
b Department of Communication Science and Disorders, Faculty of Health and Welfare , Prefectural University of Hiroshima , Mihara , Hiroshima , Japan.
出版信息
Acta Otolaryngol. 2016;136(5):528-31. doi: 10.3109/00016489.2015.1129070. Epub 2016 Jan 25.
CONCLUSION
Application of topical estriol ointment is an effective treatment for hereditary hemorrhagic telangiectasia (HHT) epistaxis.
OBJECTIVE
HHT is an autosomal-dominant disease characterized by epistaxis in more than 96% of patients. Management of this major symptom, epistaxis, has not been standardized. This study reports experience with topical application of estriol in patients with HHT.
METHODS
Five patients with a confirmed diagnosis of HHT who first visited the hospital between 2012 and 2013 received 0.1% estriol ointment and were guided to apply the ointment twice daily to the anterior part of both nasal cavities. Severity of epistaxis was valued using epistaxis severity score (ESS) before and 3 months after initiating therapy.
RESULTS
Five patients (three males, two females) received treatment. After the initiation of treatment, intensity and frequency of epistaxis became moderate in all patients. ESS decreased significantly from pre- to post-treatment (p = 0.043). No adverse events were recorded during follow-up.
结论
局部应用雌三醇软膏是治疗遗传性出血性毛细血管扩张症（HHT）鼻出血的有效方法。
目的
HHT是一种常染色体显性疾病，超过96%的患者有鼻出血症状。鼻出血这一主要症状的治疗方法尚未标准化。本研究报告了局部应用雌三醇治疗HHT患者的经验。
方法
2012年至2013年间首次到医院就诊的5例确诊为HHT的患者，接受0.1%雌三醇软膏治疗，并指导其每天两次将软膏涂抹于双侧鼻腔前部。在开始治疗前及治疗3个月后，使用鼻出血严重程度评分（ESS）评估鼻出血的严重程度。
结果
5例患者（3例男性，2例女性）接受了治疗。开始治疗后，所有患者鼻出血的强度和频率均变为中度。ESS从治疗前到治疗后显著降低（p = 0.043）。随访期间未记录到不良事件。
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