Weingarten Toby N, Thompson Lauren T, Licatino Lauren K, Bailey Christopher H, Schroeder Darrell R, Sprung Juraj
Department of Anesthesiology and.
Department of Anesthesiology and.
J Cardiothorac Vasc Anesth. 2016 Apr;30(2):323-9. doi: 10.1053/j.jvca.2015.10.019. Epub 2015 Nov 3.
To examine association of presenting clinical acuity and Glasgow Aneurysm Score (GAS) with perioperative and 1-year mortality.
Retrospective chart review.
Major tertiary care facility.
Patients with ruptured abdominal aortic aneurysm (rAAA) from 2003 through 2013.
Emergency repair of rAAA.
The authors reviewed outcomes after stable versus unstable presentation and by GAS. Unstable presentation included hypotension, cardiac arrest, loss of consciousness, and preoperative tracheal intubation. In total, 125 patients (40 stable) underwent repair. Perioperative mortality rates were 41% and 12% in unstable and stable patients, respectively (p<0.001). Unstable status had 88% sensitivity and 41% specificity for predicting perioperative mortality. Using logistic regression, higher GAS was associated with perioperative mortality (p<0.001). Using receiver operating characteristic analysis, the area under the curve was 0.72 (95% CI, 0.62-0.82) and cutoff GAS≥96 had 63% and 72% sensitivity and specificity, respectively. Perioperative mortality for GAS≥96 was 51% (25/49), whereas it was 20% (15/76) for GAS≤95. The estimated 1-year survival (95% CI) was 75% (62%-91%) for stable patients and 48% (38%-60%) for unstable patients. Estimated 1-year survival (95% CI) was 23% (13%-40%) for GAS≥96 and 77% (67%-87%) for GAS≤95.
Clinical presentation and GAS identified patients with rAAA who were likely to have a poor surgical outcome. GAS≥96 was associated with poor long-term survival, but>20% of these patients survived 1 year. Thus, neither clinical presentation nor GAS provided reliable guidance for decisions regarding futility of surgery.
探讨初始临床严重程度及格拉斯哥动脉瘤评分(GAS)与围手术期及1年死亡率之间的关联。
回顾性病历审查。
大型三级医疗保健机构。
2003年至2013年期间腹主动脉瘤破裂(rAAA)患者。
rAAA的急诊修复。
作者回顾了病情稳定与不稳定患者以及根据GAS分组的患者的预后情况。不稳定病情包括低血压、心脏骤停、意识丧失及术前气管插管。共有125例患者(40例病情稳定)接受了修复手术。不稳定和稳定患者的围手术期死亡率分别为41%和12%(p<0.001)。不稳定状态预测围手术期死亡率的敏感度为88%,特异度为41%。采用逻辑回归分析,较高的GAS与围手术期死亡率相关(p<0.001)。通过受试者工作特征分析,曲线下面积为0.72(95%CI,0.62 - 0.82),GAS≥96的临界值敏感度和特异度分别为63%和72%。GAS≥96患者的围手术期死亡率为51%(25/49),而GAS≤95患者为20%(15/76)。稳定患者的估计1年生存率(95%CI)为75%(62% - 91%),不稳定患者为48%(38% - 60%)。GAS≥96患者的估计1年生存率(95%CI)为23%(13% - 40%),GAS≤95患者为77%(67% - 87%)。
临床表现及GAS可识别出rAAA患者中手术预后可能较差的患者。GAS≥96与长期生存率低相关,但这些患者中有>20%存活超过1年。因此,临床表现和GAS均未为关于手术无意义的决策提供可靠指导。