波兰在复发性流产女性中进行父方淋巴细胞免疫治疗的经验。
Polish experiences with paternal lymphocyte immunization in women with recurrent miscarriages.
作者信息
Motak-Pochrzest Hanna, Malinowski Andrzej
机构信息
The Opole University of Technology, Faculty of Physical Education and Physiotherapy, Opole, Poland.
Department of Operational and Endoscopic Gynecology of Polish Mother's Memorial Hospital - Research Institute, Lodz, Poland.
出版信息
Neuro Endocrinol Lett. 2015 Dec;36(6):572-7.
OBJECTIVE
This study aimed to evaluate the efficacy of PLI and results of subsequent pregnancy in women with RM showing alloimmune response.
MATERIALS AND METHODS
Immunological investigations were performed in patients with RM. Subsequently, PLI was administered to 241 patients at their request. Of these, 202 conceived between September 2005 and September 2012.
RESULTS
Of the 202 women, 169 pregnancies resulted in term delivery; the remaining 33 resulted in subsequent miscarriages (success rate = 83.7%). During seven-years observations of 202 tested individuals, 114 women were pregnant again for the second time and 92 pregnancies of them resulted in the next term delivery (success rate =80.7%).
CONCLUSIONS
Alloimmune background indicated that PLI might improve pregnancy outcome in patients suffering from RM. Long-term monitoring did not reveal any negative effects of PLI on the immunological system in the treated women or newborn babies.
目的
本研究旨在评估淋巴细胞主动免疫（PLI）对有同种免疫反应的复发性流产（RM）女性的疗效及后续妊娠结果。
材料与方法
对RM患者进行免疫学检查。随后，应241例患者的要求给予PLI治疗。其中，202例在2005年9月至2012年9月期间受孕。
结果
202例女性中，169例妊娠至足月分娩；其余33例随后流产（成功率=83.7%）。在对202例受测个体进行的七年观察中，114名女性再次怀孕，其中92例妊娠至下一胎足月分娩（成功率=80.7%）。
结论
同种免疫背景表明，PLI可能改善RM患者的妊娠结局。长期监测未发现PLI对接受治疗的女性或新生儿免疫系统有任何负面影响。
Zotero 插件