核质运输的扰动会影响人类细胞中细胞核和核仁的大小。
Perturbation of nucleo-cytoplasmic transport affects size of nucleus and nucleolus in human cells.
作者信息
Ganguly Abira, Bhattacharjee Chumki, Bhave Madhura, Kailaje Vaishali, Jain Bhawik K, Sengupta Isha, Rangarajan Annapoorni, Bhattacharyya Dibyendu
机构信息
Advanced Centre for Treatment Research & Education in Cancer (ACTREC), Tata Memorial Centre, Navi Mumbai, Maharashtra, India.
Department of Molecular Reproduction, Development and Genetics, Indian Institute of Science Bangalore, India.
出版信息
FEBS Lett. 2016 Mar;590(5):631-43. doi: 10.1002/1873-3468.12077. Epub 2016 Feb 25.
Size regulation of human cell nucleus and nucleolus are poorly understood subjects. 3D reconstruction of live image shows that the karyoplasmic ratio (KR) increases by 30-80% in transformed cell lines compared to their immortalized counterpart. The attenuation of nucleo-cytoplasmic transport causes the KR value to increase by 30-50% in immortalized cell lines. Nucleolus volumes are significantly increased in transformed cell lines and the attenuation of nucleo-cytoplasmic transport causes a significant increase in the nucleolus volume of immortalized cell lines. A cytosol and nuclear fraction swapping experiment emphasizes the potential role of unknown cytosolic factors in nuclear and nucleolar size regulation.
人类细胞核和核仁的大小调控是尚未被充分理解的课题。活细胞图像的三维重建显示，与永生化细胞系相比，转化细胞系中的核质比（KR）增加了30 - 80%。核质运输的减弱会使永生化细胞系中的KR值增加30 - 50%。转化细胞系中的核仁体积显著增加，而核质运输的减弱会导致永生化细胞系的核仁体积显著增大。一项细胞质和细胞核组分交换实验强调了未知细胞质因子在细胞核和核仁大小调控中的潜在作用。
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