用于动脉粥样硬化消退的生物可吸收支架：对临时支架的理解。

Kharlamov Alexander N

De Haar Research Foundation, Handelsplein 15, Rotterdam 3071PR, The Netherlands.

Curr Cardiol Rev. 2016;12(1):66-82. doi: 10.2174/1573403x1201160126125853.

This review focuses on the clinical and biological features of the bioresorbable scaffolds in interventional cardiology highlighting scientific achievements and challenges of the transient scaffolding with Absorb BVS. Special attention is granted to the vascular biology pathways which, involved in the resorption of scaffold, artery remodeling and mechanisms of Glagovian atheroregression setting the stage for subsequent clinical applications. Twenty five years ago Glagov described the phenomenon of limited external elastic membrane enlargement in response to an increase in plaque burden. We believe this threshold becomes the target for development of strategies that reverse atherosclerosis, and particularly transient scaffolding has a potential to be a tool to ultimately conquer atherosclerosis.

本综述聚焦于介入心脏病学中生物可吸收支架的临床和生物学特性，着重介绍了Absorb生物可吸收血管支架（BVS）这一临时支架的科学成就与挑战。特别关注了参与支架吸收、动脉重塑以及Glagov动脉粥样硬化消退机制的血管生物学途径，为后续临床应用奠定基础。25年前，Glagov描述了外弹力膜在斑块负荷增加时扩张受限的现象。我们认为，这一阈值成为了逆转动脉粥样硬化策略的开发目标，尤其是临时支架有潜力成为最终攻克动脉粥样硬化的工具。