Academy of Immunology and Microbiology, Institute for Basic Science, Pohang, Republic of Korea. Department of Integrative Biosciences and Biotechnology, Pohang University of Science and Technology, Pohang, Republic of Korea.
Academy of Immunology and Microbiology, Institute for Basic Science, Pohang, Republic of Korea. Department of Integrative Biosciences and Biotechnology, Pohang University of Science and Technology, Pohang, Republic of Korea. Division of Developmental Immunology, La Jolla Institute for Allergy and Immunology, La Jolla, CA 92037, USA.
Science. 2016 Feb 19;351(6275):858-63. doi: 10.1126/science.aac5560. Epub 2016 Jan 28.
Dietary antigens are normally rendered nonimmunogenic through a poorly understood "oral tolerance" mechanism that involves immunosuppressive regulatory T (Treg) cells, especially Treg cells induced from conventional T cells in the periphery (pTreg cells). Although orally introducing nominal protein antigens is known to induce such pTreg cells, whether a typical diet induces a population of pTreg cells under normal conditions thus far has been unknown. By using germ-free mice raised and bred on an elemental diet devoid of dietary antigens, we demonstrated that under normal conditions, the vast majority of the small intestinal pTreg cells are induced by dietary antigens from solid foods. Moreover, these pTreg cells have a limited life span, are distinguishable from microbiota-induced pTreg cells, and repress underlying strong immunity to ingested protein antigens.
膳食抗原通常通过一种尚未完全了解的“口服耐受”机制变得非免疫原性，该机制涉及免疫抑制性调节性 T（Treg）细胞，特别是在外周诱导的常规 T 细胞中诱导的 Treg 细胞（pTreg 细胞）。尽管已知口服引入名义蛋白抗原可诱导此类 pTreg 细胞，但在正常情况下，典型饮食是否会诱导产生大量 pTreg 细胞迄今尚不清楚。通过使用在不含膳食抗原的元素饮食上饲养和繁殖的无菌小鼠，我们证明在正常情况下，绝大多数小肠 pTreg 细胞是由固体食物中的膳食抗原诱导的。此外，这些 pTreg 细胞具有有限的寿命，与微生物群诱导的 pTreg 细胞不同，并且抑制对摄入的蛋白抗原的潜在强烈免疫反应。
