Choudhury A, Mistry N F, Antia N H
Foundation for Medical Research, Bombay, India.
Scand J Immunol. 1989 Oct;30(4):505-9. doi: 10.1111/j.1365-3083.1989.tb02457.x.
The association of Mycobacterium leprae with Schwann cells may represent an early crucial step in M. leprae pathogenesis. Using a dissociated Schwann-cell system and anti-mycobacterial monoclonal and polyclonal antibodies directed against surface and cytoplasmic components, we investigated the nature of M. leprae epitopes that mediate cytadhesion. Antibodies to polysaccharide and lipid components of M. leprae cell wall inhibited cytadhesion, whereas those directed against both surface and cytoplasmic protein epitopes did not show any such effect. No synergistic or antagonistic activity in inhibiting cytadhesion was observed when antibodies were used in combination. Thus, the association of M. leprae with Schwann cells may be mediated collectively by more than one of its lipid/polysaccharide epitopes. Also, a role for humoral immunity in intervention in the initial steps of M. leprae pathogenesis needs to be considered.
麻风分枝杆菌与施万细胞的关联可能是麻风分枝杆菌致病机制中的一个早期关键步骤。我们使用解离的施万细胞系统以及针对表面和细胞质成分的抗分枝杆菌单克隆和多克隆抗体，研究了介导细胞黏附的麻风分枝杆菌表位的性质。针对麻风分枝杆菌细胞壁多糖和脂质成分的抗体可抑制细胞黏附，而针对表面和细胞质蛋白表位的抗体则未显示出任何此类作用。当联合使用抗体时，未观察到抑制细胞黏附的协同或拮抗活性。因此，麻风分枝杆菌与施万细胞的关联可能由其多种脂质/多糖表位共同介导。此外，需要考虑体液免疫在干预麻风分枝杆菌致病初始步骤中的作用。
