Rummeny E, Saini S, Stark D D, Weissleder R, Compton C C, Ferrucci J T
Department of Radiology, Massachusetts General Hospital, Boston.
AJR Am J Roentgenol. 1989 Dec;153(6):1207-11. doi: 10.2214/ajr.153.6.1207.
The purpose of this study was to compare the sensitivity of T1-weighted and T2-weighted spin-echo (SE) pulse sequences with T2-weighted phase-contrast (PC) imaging techniques for the detection of hepatic metastases. Pulse-sequences performance was evaluated in 52 consecutive patients with 88 hepatic metastases who underwent MR imaging at 0.6 T. Lesion-liver contrast-to-noise ratios (CNR) on SE 260/14 (-12.4 +/- 6.7) and PC 2350/60 (+10.8 +/- 4.2) images were significantly (p less than .05) greater than on SE 2350/60 (+ 7.8 +/- 3.9), SE 2350/120 (+8.1 +/- 4.8), SE 2350/180 (+7.9 +/- 4.5), and PC 2350/30 (+4.6 +/- 2.9) images. Sensitivity for detection of 88 individual metastases was comparable on SE 260/14 (78 of 88 patients) and PC 2350/60 (81 of 88 patients) images and was significantly (p less than .05) greater than on in-phase T2-weighted SE images (TE = 60, 70 of 88 patients; TE = 120, 69 of 88 patients; TE = 180, 65 of 88 patients). Histologic analysis of tumor-free liver showed fatty change in 11 of 13 specimens available for pathologic evaluation. In all 11 of those patients, PC images increased tumor-liver contrast in comparison with the in-phase SE images. This analysis suggests that for detection of hepatic metastases at midfield strengths, the T1-weighted, short TR/short TE (SE 260/14) and the T2-weighted, phase-contrast (PC 2350/60) pulse sequences offer comparable performance.
本研究的目的是比较T1加权和T2加权自旋回波（SE）脉冲序列与T2加权相位对比（PC）成像技术在检测肝转移瘤方面的敏感性。对52例连续患者共88个肝转移瘤进行了0.6T磁共振成像，评估了脉冲序列的性能。SE 260/14（-12.4±6.7）和PC 2350/60（+10.8±4.2）图像上的病灶-肝脏对比噪声比（CNR）显著（p<0.05）高于SE 2350/60（+7.8±3.9）、SE 2350/120（+8.1±4.8）、SE 2350/180（+7.9±4.5）和PC 2350/30（+4.6±2.9）图像。在SE 260/14（88例患者中的78例）和PC 2350/60（88例患者中的81例）图像上检测88个单个转移瘤的敏感性相当，且显著（p<0.05）高于同相位T2加权SE图像（TE = 60，88例患者中的70例；TE = 120，88例患者中的69例；TE = 180，88例患者中的65例）。对无肿瘤肝脏的组织学分析显示，13个可用于病理评估的标本中有11个出现脂肪变。在所有11例患者中，与同相位SE图像相比，PC图像增加了肿瘤-肝脏对比。该分析表明，对于中场强度下肝转移瘤的检测，T1加权、短TR/短TE（SE 260/14）和T2加权、相位对比（PC 2350/60）脉冲序列具有相当的性能。
