King Bryan H
Department of Psychiatry and Behavioral Sciences, University of Washington and Seattle Children's Hospital, Seattle, Washington, USA.
Curr Opin Neurol. 2016 Apr;29(2):113-7. doi: 10.1097/WCO.0000000000000299.
Recent changes in the diagnostic criteria for psychiatric and neurodevelopmental disorders as well as increases in the prevalence of both have elevated the focus on these areas of medicine and their clinical overlap.
Several recent studies have examined psychiatric comorbidities in neurodevelopmental disorders including autism and specific genetic syndromes. A growing number of reports underscore the genetic overlap between previously distinct clinical disorders. Behavioral and psychiatric features are increasingly identified in association with intellectual developmental disorders.
As there have been advances in our collective understanding of the genetic underpinnings of certain disorders and the downstream physiological consequences of those genetic alterations, challenges to the way boundaries have been drawn around psychiatric disorders, and by extension, the concept of comorbidity, warrant review.
精神疾病和神经发育障碍的诊断标准最近发生了变化,且这两类疾病的患病率均有所上升,这使得人们更加关注医学的这些领域及其临床重叠情况。
最近的几项研究调查了神经发育障碍(包括自闭症和特定遗传综合征)中的精神疾病共病情况。越来越多的报告强调了以前不同临床疾病之间的遗传重叠。行为和精神特征越来越多地与智力发育障碍相关联。
随着我们对某些疾病的遗传基础以及这些基因改变的下游生理后果的集体认识取得进展,对精神疾病界定方式的挑战,进而对共病概念的挑战,值得审视。