Choi Ja Young, Jung Soojin, Rha Dong Wook, Park Eun Sook
Department of Rehabilitation Medicine, Severance Hospital, Research Institute of Rehabilitation Medicine, Yonsei University College of Medicine, Seoul, Korea.
Yonsei Med J. 2016 Mar;57(2):496-504. doi: 10.3349/ymj.2016.57.2.496.
To investigate the effect of intramuscular Botulinum toxin type A (BoNT-A) injection on gait and dynamic foot pressure distribution in children with spastic cerebral palsy (CP) with dynamic equinovarus foot.
Twenty-five legs of 25 children with CP were investigated in this study. BoNT-A was injected into the gastrocnemius (GCM) and tibialis posterior (TP) muscles under the guidance of ultrasonography. The effects of the toxin were clinically assessed using the modified Ashworth scale (MAS) and modified Tardieu scale (MTS), and a computerized gait analysis and dynamic foot pressure measurements using the F-scan system were also performed before injection and at 1 and 4 months after injection.
Spasticity of the ankle plantar-flexor in both the MAS and MTS was significantly reduced at both 1 and 4 months after injection. On dynamic foot pressure measurements, the center of pressure index and coronal index, which represent the asymmetrical weight-bearing of the medial and lateral columns of the foot, significantly improved at both 1 and 4 months after injection. The dynamic foot pressure index, total contact area, contact length and hind foot contact width all increased at 1 month after injection, suggesting better heel contact. Ankle kinematic data were significantly improved at both 1 and 4 months after injection, and ankle power generation was significantly increased at 4 months after injection compared to baseline data.
Using a computerized gait analysis and foot scan, this study revealed significant benefits of BoNT-A injection into the GCM and TP muscles for dynamic equinovarus foot in children with spastic CP.
探讨A型肉毒杆菌毒素(BoNT-A)肌肉注射对痉挛型脑性瘫痪(CP)合并动态马蹄内翻足患儿步态及动态足底压力分布的影响。
本研究纳入了25例CP患儿的25条腿。在超声引导下将BoNT-A注射到腓肠肌(GCM)和胫后肌(TP)中。使用改良Ashworth量表(MAS)和改良Tardieu量表(MTS)对毒素的效果进行临床评估,并且在注射前、注射后1个月和4个月进行计算机化步态分析以及使用F-scan系统进行动态足底压力测量。
注射后1个月和4个月时,MAS和MTS评估的踝关节跖屈肌痉挛均显著减轻。在动态足底压力测量中,代表足内侧和外侧柱不对称负重的压力中心指数和冠状指数在注射后1个月和4个月时均显著改善。注射后1个月时,动态足底压力指数、总接触面积、接触长度和后足接触宽度均增加,提示足跟接触改善。注射后1个月和4个月时踝关节运动学数据均显著改善,与基线数据相比,注射后4个月时踝关节发电能力显著增加。
本研究通过计算机化步态分析和足部扫描显示,向GCM和TP肌肉注射BoNT-A对痉挛型CP患儿的动态马蹄内翻足有显著益处。