Department of Microbiology, Medicinal Plants Research Center of Barij, PO 3795191916, Kashan, Iran.
Department of Microbiology, Medicinal Plants Research Center of Barij, PO 3795191916, Kashan, Iran.
J Mycol Med. 2016 Mar;26(1):e6-10. doi: 10.1016/j.mycmed.2015.11.003. Epub 2016 Feb 2.
Candida albicans is the common cause of some infectious diseases such as vaginal candidiasis or candidemia. Due to the emergence of drug resistant isolates of C. albicans, finding a new anti-Candida agent is a new strategy for current treatments. This study evaluated the anti-candidal activity of Satureja khuzistanica ethanol extract against clinical isolates of C. albicans. S. khuzistanica ethanol extract from aerial parts of plant at full flowering stage was evaluated against 30 clinical isolates and two ATCC reference strains of C. albicans by disc diffusion and micro-broth dilution assay. Also, in this study we evaluated the synergistic effects of amphotericin B, clotrimazole and ketoconazole with S. khuzistanica ethanol extract. The means of MIC and MFC of S. khuzistanica ethanol extract against clinical isolates were 299.4 and 722.6 (μg/mL), respectively. S. khuzistanica ethanol extract increased the anti-candidal effect of amphotericin B and ketoconazole, while it had no synergistic effect on clotrimazole against clinical isolates of C. albicans. Therefore, S. khuzistanica ethanol extract can be introduced as a new source of anti-candidal agent against clinical isolates of C. albicans.
白色念珠菌是一些传染病的常见病因，如阴道念珠菌病或念珠菌血症。由于耐药的白色念珠菌分离株的出现，寻找新的抗念珠菌药物是当前治疗的新策略。本研究评估了香薷乙醇提取物对临床分离的白色念珠菌的抗真菌活性。采用琼脂扩散法和微量肉汤稀释法，对来自植物开花期地上部分的香薷乙醇提取物对 30 株临床分离株和 2 株白色念珠菌 ATCC 参考株进行了评估。此外，本研究还评估了两性霉素 B、克霉唑和酮康唑与香薷乙醇提取物的协同作用。香薷乙醇提取物对临床分离株的 MIC 和 MFC 值分别为 299.4 和 722.6(μg/mL)。香薷乙醇提取物增加了两性霉素 B 和酮康唑的抗真菌作用，而对克霉唑对白色念珠菌临床分离株无协同作用。因此，香薷乙醇提取物可以作为一种新的抗念珠菌药物来源，用于治疗白色念珠菌临床分离株。
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